4,6-DIFLUORO-3-IODOINDAZOLE

Base Information

• Chemical Name: 4,6-DIFLUORO-3-IODOINDAZOLE
• CAS No.: 887567-79-5
• Molecular Formula: C₇H₃F₂IN₂
• Molecular Weight: 280.016
• Mol file: 887567-79-5.mol

Synonyms:4,6-DIFLUORO-3-IODOINDAZOLE;4,6-Difluoro-3-iodo-1H-indazole

Chemical Property of 4,6-DIFLUORO-3-IODOINDAZOLE

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

4,6-Difluoro-3-iodo-1H-indazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-DIFLUORO-3-IODOINDAZOLE

There total 2 articles about 4,6-DIFLUORO-3-IODOINDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,6-difluoro-1H-indazole (885520-26-3) → 4,6-difluoro-3-iodo-1H-indazole (887567-79-5)

Guidance literature:

With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

2,4,6-trifluorobenzaldehyde (58551-83-0) → 4,6-difluoro-3-iodo-1H-indazole (887567-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate; N-methoxylamine hydrochloride / 1,2-dimethoxyethane / 5 h / 50 °C

1.2: 2 h / 100 °C

2.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

With iodine; N-methoxylamine hydrochloride; potassium carbonate; potassium hydroxide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;

upstream raw materials:

4,6-difluoro-1H-indazole

2,4,6-trifluorobenzaldehyde

Refernces