Technology Process of 3H-Imidazo[4,5-c]pyridine, 4,7-difluoro-
There total 10 articles about 3H-Imidazo[4,5-c]pyridine, 4,7-difluoro- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 84 percent / aq. ammonium hydroxide / 1.5 h / 20 °C
2: 86 percent / triethylamine; H2 / Pd/C / ethanol / 24 h / 2585.74 Torr
3: 73 percent / potassium nitrate; sulfuric acid / 1.42 h / 4 - 20 °C
4: 87 percent / sulfuric acid / 24 h / 20 °C
5: 95 percent / H2 / Raney nickel / ethanol / 3 h / 1861.73 Torr
6: 78 percent / 1.5 h / 100 °C
With
ammonium hydroxide; sulfuric acid; hydrogen; potassium nitrate; triethylamine;
palladium on activated charcoal; nickel;
In
ethanol;
DOI:10.1016/j.tetlet.2005.03.190
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 83 percent / acetonitrile / 0.5 h / Heating
2: 95 percent / trifluoroacetic acid / 6 h / 70 °C
3: 100 percent / tert-butyl nitrite / tetrahydrofuran / 10 h / 60 °C
4: 84 percent / aq. ammonium hydroxide / 1.5 h / 20 °C
5: 86 percent / triethylamine; H2 / Pd/C / ethanol / 24 h / 2585.74 Torr
6: 73 percent / potassium nitrate; sulfuric acid / 1.42 h / 4 - 20 °C
7: 87 percent / sulfuric acid / 24 h / 20 °C
8: 95 percent / H2 / Raney nickel / ethanol / 3 h / 1861.73 Torr
9: 78 percent / 1.5 h / 100 °C
With
ammonium hydroxide; tert.-butylnitrite; sulfuric acid; hydrogen; potassium nitrate; triethylamine; trifluoroacetic acid;
palladium on activated charcoal; nickel;
In
tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/j.tetlet.2005.03.190
