Technology Process of Boronic acid, B-(5-methyl-1H-indol-4-yl)-
There total 4 articles about Boronic acid, B-(5-methyl-1H-indol-4-yl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-bromo-5-methyl-1H-indole;
With
tert.-butyl lithium; potassium hydride;
In
diethyl ether; pentane;
at -78 - 0 ℃;
for 1h;
With
boric acid tributyl ester;
In
diethyl ether; pentane;
at -78 - 20 ℃;
for 25h;
With
phosphoric acid;
In
diethyl ether; water; pentane;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: nitric acid / acetic acid / 3 h / 0 - 80 °C
2.1: N,N-dimethyl-formamide / 5 h / 20 - 125 °C
3.1: acetic anhydride; zinc / water / 4 h / 110 °C
4.1: tert.-butyl lithium; potassium hydride / diethyl ether; pentane / 1 h / -78 - 0 °C
4.2: 25 h / -78 - 20 °C
With
tert.-butyl lithium; nitric acid; acetic anhydride; potassium hydride; zinc;
In
diethyl ether; water; acetic acid; N,N-dimethyl-formamide; pentane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N-dimethyl-formamide / 5 h / 20 - 125 °C
2.1: acetic anhydride; zinc / water / 4 h / 110 °C
3.1: tert.-butyl lithium; potassium hydride / diethyl ether; pentane / 1 h / -78 - 0 °C
3.2: 25 h / -78 - 20 °C
With
tert.-butyl lithium; acetic anhydride; potassium hydride; zinc;
In
diethyl ether; water; N,N-dimethyl-formamide; pentane;
