3H-Pyrrolo[3,4-c]pyridin-3-one, 4,6-dichloro-7-fluoro-1,2-dihydro-

Base Information

• Chemical Name: 3H-Pyrrolo[3,4-c]pyridin-3-one, 4,6-dichloro-7-fluoro-1,2-dihydro-
• CAS No.: 1312693-69-8
• Molecular Formula: C7H3Cl2FN2O
• Molecular Weight: 221.01600
• Hs Code.: 2933399990
• Mol file: 1312693-69-8.mol

Synonyms:3H-Pyrrolo[3,4-c]pyridin-3-one, 4,6-dichloro-7-fluoro-1,2-dihydro-;

Chemical Property of 3H-Pyrrolo[3,4-c]pyridin-3-one, 4,6-dichloro-7-fluoro-1,2-dihydro-

Chemical Property:

• PSA: 41.99000
• LogP: 2.09970
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

4,6-Dichloro-7-fluoro-1H-pyrrolo[3,4-c]pyridin-3(2H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-Pyrrolo[3,4-c]pyridin-3-one, 4,6-dichloro-7-fluoro-1,2-dihydro-

There total 3 articles about 3H-Pyrrolo[3,4-c]pyridin-3-one, 4,6-dichloro-7-fluoro-1,2-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4,6-dichloro-7-fluoro-1-hydroxy-1H-pyrrolo[3,4-c]pyridin-3(2H)-one (1312693-68-7) → 4,6-dichloro-7-fluoro-1H-pyrrolo[3,4-c]pyridin-3(2H)-one (1312693-69-8)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 - 40 ℃; for 10h; Inert atmosphere; Large scale;

Reference yield:

2,6-dichloro-5-fluoropyridine-3-carboxamide (113237-20-0) → 4,6-dichloro-7-fluoro-1H-pyrrolo[3,4-c]pyridin-3(2H)-one (1312693-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 5 °C / 760.05 Torr / Inert atmosphere

2: trifluoroacetic acid; triethylsilane / dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere; Reflux

With triethylsilane; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

2,6-dichloro-5-fluoro-pyridine-3-carbonitrile (82671-02-1) → 4,6-dichloro-7-fluoro-1H-pyrrolo[3,4-c]pyridin-3(2H)-one (1312693-69-8)

Guidance literature:

Multi-step reaction with 3 steps

1: water; sulfuric acid / 21 - 65 °C / 760.05 Torr / Inert atmosphere; Industry scale

2: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 5 °C / 760.05 Torr / Inert atmosphere

3: trifluoroacetic acid; triethylsilane / dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere; Reflux

With triethylsilane; sulfuric acid; water; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

upstream raw materials:

2,6-dichloro-5-fluoropyridine-3-carboxamide

2,6-dichloro-5-fluoro-pyridine-3-carbonitrile

4,6-dichloro-7-fluoro-1-hydroxy-1H-pyrrolo[3,4-c]pyridin-3(2H)-one

Downstream raw materials:

tert-butyl 4,6-dichloro-7-fluoro-3-oxo-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate

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