Imidazo[1,5-a]pyrazine-7(8H)-carboxylic acid, 1-bromo-5,6-dihydro-3-(trifluoromethyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Imidazo[1,5-a]pyrazine-7(8H)-carboxylic acid, 1-bromo-5,6-dihydro-3-(trifluoromethyl)-, 1,1-dimethylethyl ester
• CAS No.: 1152440-02-2
• Molecular Formula: C12H15BrF3N3O2
• Molecular Weight: 370.16600
• Mol file: 1152440-02-2.mol

Synonyms:1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester;tert-butyl 1-bromo-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxylate;

Chemical Property of Imidazo[1,5-a]pyrazine-7(8H)-carboxylic acid, 1-bromo-5,6-dihydro-3-(trifluoromethyl)-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 47.36000
• LogP: 3.35300

Purity/Quality:

NLT 98% ^*data from raw suppliers

tert-Butyl1-bromo-3-(trifluoromethyl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Imidazo[1,5-a]pyrazine-7(8H)-carboxylic acid, 1-bromo-5,6-dihydro-3-(trifluoromethyl)-, 1,1-dimethylethyl ester

There total 6 articles about Imidazo[1,5-a]pyrazine-7(8H)-carboxylic acid, 1-bromo-5,6-dihydro-3-(trifluoromethyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.8%

tert-butyl 3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxylate (1152440-01-1) → tert-butyl 1-bromo-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxylate (1152440-02-2)

Guidance literature:

With N-Bromosuccinimide; In ethanol; at 20 ℃; for 1h;

Reference yield:

2,2,2-trifluoro-N-(pyrazin-2-ylmethyl)acetamide (1152439-76-3) → tert-butyl 1-bromo-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxylate (1152440-02-2)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus pentoxide; trichlorophosphate / 6 h / Reflux

2: triethylamine / tetrahydrofuran

3: N-Bromosuccinimide / ethanol / 7 h / 20 °C

With N-Bromosuccinimide; phosphorus pentoxide; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol;

Reference yield:

2-aminomethylpyrazine (20010-99-5) → tert-butyl 1-bromo-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxylate (1152440-02-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 12 h / 0 - 20 °C

2: phosphorus pentoxide; trichlorophosphate / 6 h / Reflux

3: triethylamine / tetrahydrofuran

4: N-Bromosuccinimide / ethanol / 7 h / 20 °C

With N-Bromosuccinimide; phosphorus pentoxide; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol;

upstream raw materials:

tert-butyl 3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-7-carboxylate

2,2,2-trifluoro-N-(pyrazin-2-ylmethyl)acetamide

2-aminomethylpyrazine

3-trifluoromethylimidazolo[1,5-a]pyrazine

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