Benzyl (5-bromopyridin-2-yl)carbamate

Base Information

• Chemical Name: Benzyl (5-bromopyridin-2-yl)carbamate
• CAS No.: 175393-09-6
• Molecular Formula: C₁₃H₁₁BrN₂O₂
• Molecular Weight: 307.147
• DSSTox Substance ID: DTXSID20442241
• Wikidata: Q82259415
• Mol file: 175393-09-6.mol

Synonyms:175393-09-6;5-Bromo-2-(Cbz-amino)pyridine;Benzyl (5-bromopyridin-2-yl)carbamate;Benzyl N-(5-bromopyridin-2-yl)carbamate;CARBAMIC ACID, (5-BROMO-2-PYRIDINYL)-,PHENYLMETHYL ESTER;SCHEMBL7090892;DTXSID20442241;XAHHPDSPSWOXMS-UHFFFAOYSA-N;MFCD11976386;Benzyl(5-bromopyridin-2-yl)carbamate;AKOS015834718;BS-21759;CS-0211877;EN300-4753977;A881577;(5-Bromo-pyridin-2-yl)-carbamic acid benzyl ester;Carbamic acid,(5-bromo-2-pyridinyl)-,phenylmethyl ester

Chemical Property of Benzyl (5-bromopyridin-2-yl)carbamate

Chemical Property:

• Storage Temp.: Room temperature.
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 306.00039
• Heavy Atom Count: 18
• Complexity: 270

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-(Cbz-amino)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NC2=NC=C(C=C2)Br

Technology Process of Benzyl (5-bromopyridin-2-yl)carbamate

There total 1 articles about Benzyl (5-bromopyridin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

5-bromo-2-pyridylamine (1072-97-5) + benzyl chloroformate (501-53-1,94274-21-2) → (5-bromo-pyridin-2-yl)-carbamic acid benzyl ester (175393-09-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chloroform; at 0 ℃; for 0.25h;

Reference yield:

-butyl vinyl ether (111-34-2,92680-80-3) + (5-bromo-pyridin-2-yl)-carbamic acid benzyl ester (175393-09-6) → (5-acetyl-pyridin-2-yl)-carbamic acid benzyl ester

Guidance literature:

With triethylamine; palladium diacetate; In acetonitrile;

Reference yield:

-butyl vinyl ether (111-34-2,92680-80-3) + (5-bromo-pyridin-2-yl)-carbamic acid benzyl ester (175393-09-6) → [5-(1-Butoxy-vinyl)-pyridin-2-yl]-carbamic acid benzyl ester + [5-((E)-2-Butoxy-vinyl)-pyridin-2-yl]-carbamic acid benzyl ester

Guidance literature:

With palladium diacetate; triethylamine; hydroquinone; tris-(o-tolyl)phosphine; In acetonitrile; for 18h; Heating;

upstream raw materials:

5-bromo-2-pyridylamine

benzyl chloroformate