1-BOC-5-INDAZOLECARBOXYLIC ACID

Base Information

• Chemical Name: 1-BOC-5-INDAZOLECARBOXYLIC ACID
• CAS No.: 885954-14-3
• Molecular Formula: C13H14N2O4
• Molecular Weight: 262.265
• Mol file: 885954-14-3.mol

Synonyms:1-BOC-5-INDAZOLECARBOXYLIC ACID;INDAZOLE-1,5-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;1-BOC-1H-INDAZOLE-5-CARBOXYLIC ACID;

Chemical Property of 1-BOC-5-INDAZOLECARBOXYLIC ACID

Chemical Property:

• PSA: 81.42000
• LogP: 2.51770
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-(tert-Butoxycarbonyl)-1H-indazole-5-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-5-INDAZOLECARBOXYLIC ACID

There total 1 articles about 1-BOC-5-INDAZOLECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

di-tert-butyl dicarbonate (24424-99-5) + 1H-indazole-5-carboxylic acid (61700-61-6) → 1-(tert-butoxycarbonyl)-1H-indazole-5-carboxylic acid (885954-14-3)

Guidance literature:

di-tert-butyl dicarbonate; 1H-indazole-5-carboxylic acid; With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 16h; Inert atmosphere;

With citric acid; In water; pH=~ 4;

Reference yield: 70.3%

1-(tert-butoxycarbonyl)-1H-indazole-5-carboxylic acid (885954-14-3) + 1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one (1021-25-6) → tert-butyl 5-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carbonyl)indazole-1-carboxylate

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield: 24.8%

1-(tert-butoxycarbonyl)-1H-indazole-5-carboxylic acid (885954-14-3) + 1-(3,4-dichlorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one → tert-butyl 5-[1-(3,4-dichlorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decane-8-carbonyl]indazole-1-carboxylate

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; Molecular sieve;

upstream raw materials:

di-tert-butyl dicarbonate

1H-indazole-5-carboxylic acid

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