61700-61-6

Basic information

• Product Name: 5-Carboxyindazole hydrochloride
• Synonyms: INDAZOLE-5-CARBOXYLIC ACID;5-CARBOXYINDAZOLE HCL;5-CARBOXYINDAZOLE HYDROCHLORIDE;5-INDAZOLECARBOXYLIC ACID;5-(1H)INDAZOLE CARBOXYLIC ACID;1H-INDAZOLE-5-CARBOXYLIC ACID;1H-Indazole-5-carboxylic acid methyl ester;Indazole-5-carboxylic acid hydrochloride
• CAS NO: 61700-61-6
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 198.61
• Product Categories: Heterocycles series;pharmacetical;Building Blocks;Indazole
• Mol File: 61700-61-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: >250℃
• Boiling Point: 443.7±18.0 °C(Predicted)
• Appearance: Yellow to amber/Spherical Beads
• Density: 1.506±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.03±0.30(Predicted)
• CAS DataBase Reference: 5-Carboxyindazole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Carboxyindazole hydrochloride(61700-61-6)
• EPA Substance Registry System: 5-Carboxyindazole hydrochloride(61700-61-6)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 61700-61-6(Hazardous Substances Data)

Usage

Uses

1H-Indazole-5-carboxylic Acid is used as a reactant in the synthesis of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists.

InChI:InChI=1/C8H6N2O2.ClH/c11-8(12)5-1-2-7-6(3-5)4-9-10-7;/h1-4H,(H,9,10)(H,11,12);1H

Upstream product

• 473416-12-5 methyl 1H-indazole-5-carboxylate 
• 543-87-3 isopentyl nitrate 
• 18595-14-7 methyl 4-amino-3-methylbenzoate 
• 144-55-8 sodium hydrogencarbonate 
• 124-38-9 carbon dioxide 
• 53857-57-1 5-bromo-1H-indazole 
• 239075-26-4 methyl N-acetyl indazole-5-carboxylate 
• 2486-70-6 4-amino 3-methylbenzoic acid 
• 24078-21-5 methyl 3-methyl-4-nitrobenzoate 
• 3113-71-1 3-methyl-4-nitrobenzoic acid 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 2258-42-6 formyl acetic anhydride 
• 74626-47-4 1H-indazole-5-carbonitrile 

Downstream Products

• 1197815-64-7 2'-(tert-butyl)-1-(1H-indazole-5-carbonyl)-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazol]-7'(6'H)-one 
• 1404449-26-8 5-(1-acetyl-1H-indazole-5-carbonyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1444004-90-3 (Z)-4-(2-(1H-indazol-5-yl)-1-(4-(2-(methylamino)ethoxy)phenyl)but-1-enyl)phenol 
• 1444004-91-4 (E)-4-(2-(1H-indazol-5-yl)-1-(4-(2-(methylamino)ethoxy)phenyl)but-1-enyl)phenol 
• 1093303-17-3 C₂₃H₁₈N₄S 
• 1093303-19-5 4-(1H-indazol-5-yl)-N,5-diphenyl-1,3-thiazol-2-amine 
• 1093302-90-9 4-(1H-indazol-5-yl)-N-(2-phenylethyl)-1,3-thiazol-2-amine 
• 1093302-88-5 N-benzyl-4-(1H-indazol-5-yl)-1,3-thiazol-2-amine 
• 1093302-85-2 4-(1H-indazol-5-yl)-N-phenyl-1,3-thiazol-2-amine 
• 1093303-23-1 2-(1H-indazol-5-yl)-3-phenylimidazo[1,2-a]pyrimidine 
• 1093306-93-4 2-bromo-1-(1H-indazol-5-yl)-2-phenylethanone 
• 1093306-92-3 tert-butyl 5-(2-phenylacetyl)-1H-indazole-1-carboxylate 
• 877264-73-8 tert-butyl 5-acetyl-1H-indazole-1-carboxylate 
• 1001906-63-3 1-(1H-indazole-5-yl)-ethanone 

Relevant articles and documents

PGDH INHIBITORS AND METHODS OF MAKING AND USING

Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

Hysteretic carbon dioxide sorption in a novel copper(ii)-indazole- carboxylate porous coordination polymer

The synthesis, structural and gas sorption studies of a porous Cu(ii) coordination polymer featuring 1H-indazole-5-carboxylic acid (H2L) are presented. [Cu(HL)2] is a thermally and hydrolytically robust 4-connected 3D coordination polymer of NbO topology and is replete with 1D channels that permit selective and hysteretic sorption of CO2. The Royal Society of Chemistry 2012.