1H-Indole-1-carboxylic acid, 4-fluoro-2,3-dihydro-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Indole-1-carboxylic acid, 4-fluoro-2,3-dihydro-, 1,1-dimethylethyl ester
CAS No.:1037075-45-8
Molecular Formula:C13H16FNO2
Molecular Weight:237.27000
Hs Code.:
Mol file:1037075-45-8.mol

Synonyms:tert-Butyl 4-fluoroindoline-1-carboxylate;

Suppliers and Price of 1H-Indole-1-carboxylic acid, 4-fluoro-2,3-dihydro-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-fluoroindoline-1-carboxylate 95+%
1g
$ 491.00

Chemenu
tert-butyl4-fluoroindoline-1-carboxylate 95%
1g
$ 464.00

Alichem
tert-Butyl4-fluoroindoline-1-carboxylate
1g
$ 400.00

Total 4 raw suppliers

Chemical Property of 1H-Indole-1-carboxylic acid, 4-fluoro-2,3-dihydro-, 1,1-dimethylethyl ester

Chemical Property:

PSA：29.54000
LogP:3.18830

Purity/Quality:

98% ^*data from raw suppliers

tert-Butyl4-fluoroindoline-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Indole-1-carboxylic acid, 4-fluoro-2,3-dihydro-, 1,1-dimethylethyl ester

There total 4 articles about 1H-Indole-1-carboxylic acid, 4-fluoro-2,3-dihydro-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 552866-98-5
2,3-dihydro-4-fluoro-1H-indole

: 1037075-45-8
1,1-dimethylethyl 4-fluoro-2,3-dihydro-1H-indole-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; dmap; at 20 ℃;

Reference yield: 98.0%

: 4248-19-5
tert-butyl carbazate

: 1037075-35-6
2-(2-fluoro-6-iodophenyl)ethyl methanesulfonate

: 1037075-45-8
1,1-dimethylethyl 4-fluoro-2,3-dihydro-1H-indole-1-carboxylate

Guidance literature:: With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol8008792

Reference yield:

: 387-43-9
4-fluoroindole

: 1037075-45-8
1,1-dimethylethyl 4-fluoro-2,3-dihydro-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride / acetic acid / 2 h / 12 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dmap / 20 °C

With sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; dmap; acetic acid;