Urease

Base Information

• Chemical Name: Urease
• CAS No.: 9002-13-5
• Molecular Formula: Unspecified
• Molecular Weight: 30.06900
• Hs Code.: 35079090

Synonyms:Urease LF;E.C.3.5.1.5;Urea amidohydrolase;Enzyme urease;Jack bean urease;Urease enzyme preparation from Lactobacillus fermentum;

Chemical Property of Urease

Chemical Property:

• Appearance/Colour: yellow powder
• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: 2-8°C
• Water Solubility.: It is slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

Urease ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-42
• Safety Statements: 22-24-26-36/37-45-36-23

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• General Description: Urease (EC 3.5.1.5), also known as urea amidohydrolase, is a nickel-dependent enzyme that catalyzes the hydrolysis of urea into ammonia and carbon dioxide. It is widely found in bacteria, plants, and fungi, playing a critical role in nitrogen metabolism. Urease is significant in both agricultural and medical contexts, as it contributes to soil nitrogen availability and is implicated in pathogenic processes, such as Helicobacter pylori infection. The enzyme's activity can be inhibited to control urea degradation or microbial virulence. Variants like jack bean urease and urease from Lactobacillus fermentum are studied for their biochemical properties and applications.

Refernces

Synthesis, structures, and urease inhibitory activities of three copper(II) and zinc(II) complexes with 2-{[2-(2-hydroxyethylamino)ethylimino] methyl}-4-nitrophenol

10.1016/j.ejmech.2010.03.012

This research aimed to explore novel urease inhibitors by synthesizing and characterizing three new mononuclear complexes of Cu(II) and Zn(II) with the Schiff base ligand 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol (HL). The purpose was to counteract the negative effects of urease activity, which is a nickel-containing enzyme that hydrolyzes urea to produce ammonia and carbamate, leading to increased ammonia concentrations and pH elevations with implications in medicine and agriculture. The study concluded that two Cu(II) complexes, [CuLNO3] (1) and [CuClL] (2), exhibited strong urease inhibitory activities with IC50 values lower than that of acetohydroxamic acid, a standard urease inhibitor, while the Zn(II) complex [Zn(CH3COO)L] (3) showed no activity at 100 mM concentration. The chemicals used in the process included 5-nitrosalicylaldehyde, N-(2-hydroxyethyl)ethylenediamine for the synthesis of HL, and metal salts such as copper nitrate, copper chloride, and zinc acetate for the formation of the respective complexes.

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