6-acetamidoindole

Base Information

• Chemical Name: 6-acetamidoindole
• CAS No.: 171896-30-3
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.19900
• Hs Code.: 2933990090
• Mol file: 171896-30-3.mol

Synonyms:N-indol-6-ylacetamide;BB_SC-8105;Acetamide,N-1H-indol-6-yl;

Chemical Property of 6-acetamidoindole

Chemical Property:

• PSA: 44.89000
• LogP: 2.19930
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

N-(1H-Indol-6-yl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-acetamidoindole

There total 6 articles about 6-acetamidoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

6-amino-1H-indole (5318-27-4) + acetic anhydride (108-24-7) → N-(1H-indol-6-yl)acetamide (171896-30-3)

Guidance literature:

In benzene; at 25 ℃; for 4.5h;

Reference yield:

6-nitroindole (4769-96-4) → N-(1H-indol-6-yl)acetamide (171896-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous N₂H₄+H₂O; Raney nickel; methanol

2: benzene

With methanol; nickel; hydrazine hydrate; benzene;

DOI:10.1021/ja01649a045

Reference yield:

2,4-dinitrotoluene (121-14-2) → N-(1H-indol-6-yl)acetamide (171896-30-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / 2 h / Heating

2: 64 percent / aluminum amalgam / H₂O / 5 h / Irradiation

3: 59 percent / benzene / 4.5 h / 25 °C

With aluminium amalgam; In water; benzene;

upstream raw materials:

6-amino-1H-indole

acetic anhydride

2,4-dinitrotoluene

(E)-2-(2,4-dinitrophenyl)-N,N-dimethyl-1-ethenamine

Refernces

• 1、 Toste, F. Dean,Still, I. W. J.. "Sonication and Aluminum Amalgam in the Leimgruber-Batcho Reaction. An Improved Preparation of 6-Aminoindole". . p. 576 - 579. Retrieved 2007/10/03.