N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE

Base Information

• Chemical Name: N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE
• CAS No.: 1026796-81-5
• Molecular Formula: C7H7BrN2O
• Molecular Weight: 215.049
• Hs Code.: 2933399090
• Mol file: 1026796-81-5.mol

Synonyms:

Chemical Property of N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE

Chemical Property:

• Boiling Point: 385.1±27.0 °C(Predicted)
• PKA: 13.15±0.70(Predicted)
• PSA: 45.48000
• Density: 1.630±0.06 g/cm3(Predicted)
• LogP: 2.45200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-(4-Bromopyridin-2-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(4-Bromopyridin-2-yl)acetamide is used as a reactant in the preparation of trisubstituted pyridinylimidazoles as potent inhibitors of the clinically resistant L858R/T790M/C797S EGFR mutant.

Technology Process of N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE

There total 3 articles about N-(4-BROMO-2-PYRIDINYL)-ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.14%

2-amino-4-bromopyridine (84249-14-9) + acetic anhydride (108-24-7) → N-(4-bromopyridin-2-yl)acetamide (1026796-81-5)

Guidance literature:

In dichloromethane; at 20 ℃; Industrial scale;

Reference yield: 95.0%

2-amino-4-bromopyridine (84249-14-9) + acetyl chloride (75-36-5) → N-(4-bromopyridin-2-yl)acetamide (1026796-81-5)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; Time; Inert atmosphere;

Reference yield: 75.0%

2-amino-4-bromopyridine (84249-14-9) + N,N-dimethyl acetamide (127-19-5,116057-81-9) → N-(4-bromopyridin-2-yl)acetamide (1026796-81-5)

Guidance literature:

With sulphuric acid immobilized on silica gel; In neat (no solvent); at 70 ℃; for 10h; Green chemistry;

DOI:10.1039/c4ra16571c

upstream raw materials:

2-amino-4-bromopyridine

acetic anhydride

acetyl chloride

N,N-dimethyl acetamide