4-Chloro-6-(3-nitrophenyl)furo[2,3-d]pyrimidine

Base Information

Chemical Name:4-Chloro-6-(3-nitrophenyl)furo[2,3-d]pyrimidine
CAS No.:475585-22-9
Molecular Formula:C12H6ClN3O3
Molecular Weight:275.64700
Hs Code.:
DSSTox Substance ID:DTXSID20591783
Wikidata:Q82485650
Mol file:475585-22-9.mol

Synonyms:475585-22-9;4-chloro-6-(3-nitrophenyl)furo[2,3-d]pyrimidine;4-chloro-6-(3-nitrophenyl)-furo[2,3-d]pyrimidine;SCHEMBL5357782;DTXSID20591783;TQR1305;ZMEWDSHUWQXBIS-UHFFFAOYSA-N;4-chloro-6-(3-nitrophenyl)furo[2.3-d]pyrimidine

Suppliers and Price of 4-Chloro-6-(3-nitrophenyl)furo[2,3-d]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
4-chloro-6-(3-nitro-phenyl)-furo[2,3-D]pyrimidine 95
10g
$ 2200.00

Total 3 raw suppliers

Chemical Property of 4-Chloro-6-(3-nitrophenyl)furo[2,3-d]pyrimidine

Chemical Property:

PSA：84.74000
LogP:3.97460
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:275.0097688
Heavy Atom Count:19
Complexity:352

Purity/Quality:

99% ^*data from raw suppliers

4-chloro-6-(3-nitro-phenyl)-furo[2,3-D]pyrimidine 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)[N+](=O)[O-])C2=CC3=C(O2)N=CN=C3Cl

Technology Process of 4-Chloro-6-(3-nitrophenyl)furo[2,3-d]pyrimidine

There total 5 articles about 4-Chloro-6-(3-nitrophenyl)furo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 475585-23-0
6-(3-nitrophenyl)furo[2,3-d]pyrimidin-4-ol

: 475585-22-9
4-chloro-6-(3-nitrophenyl)furo[2,3-d]pyrimidine

Guidance literature:: With trichlorophosphate; for 4h; Heating;
DOI:10.1002/hlca.200490089

Reference yield:

: 52119-38-7
ethyl 3-oxo-3-(3-nitrophenyl)propanoate

: 475585-22-9
4-chloro-6-(3-nitrophenyl)furo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 92 percent / SO₂Cl₂ / toluene / 0.25 h / 20 °C

2.1: 61.98 g / tetrahydrofuran / 3 h / 25 °C

3.1: formic acid / dimethylformamide / 24 h / 140 °C

3.2: NaOH / H₂O / 0.5 h / 100 °C

4.1: Cu₂O / quinoline / 1 h / 190 °C

5.1: 23 percent / POCl₃ / 4 h / Heating

With formic acid; sulfuryl dichloride; trichlorophosphate; copper(I) oxide; In tetrahydrofuran; quinoline; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.200490089

Reference yield:

: 792916-32-6
2-chloro-3-(3-nitro-phenyl)-3-oxo-propionic acid ethyl ester

: 475585-22-9
4-chloro-6-(3-nitrophenyl)furo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 61.98 g / tetrahydrofuran / 3 h / 25 °C

2.1: formic acid / dimethylformamide / 24 h / 140 °C

2.2: NaOH / H₂O / 0.5 h / 100 °C

3.1: Cu₂O / quinoline / 1 h / 190 °C

4.1: 23 percent / POCl₃ / 4 h / Heating

With formic acid; trichlorophosphate; copper(I) oxide; In tetrahydrofuran; quinoline; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200490089