6-Bromo-1,5-dimethyl-1H-indazole

Base Information

• Chemical Name: 6-Bromo-1,5-dimethyl-1H-indazole
• CAS No.: 1159511-83-7
• Molecular Formula: C9H9BrN2
• Molecular Weight: 225.08500
• Hs Code.: 2933990090
• Mol file: 1159511-83-7.mol

Synonyms:C-2370;6-Bromo-1,5-dimethyl-1H-indazole;

Chemical Property of 6-Bromo-1,5-dimethyl-1H-indazole

Chemical Property:

• PSA: 17.82000
• LogP: 2.64420

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-1,5-dimethyl-1H-indazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-1,5-dimethyl-1H-indazole

There total 1 articles about 6-Bromo-1,5-dimethyl-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

6-bromo-5-methyl-1H-indazole (1000343-69-0,1337530-20-7) + methyl iodide (74-88-4) → 6-bromo-1,5-dimethyl-1H-indazole (1159511-83-7) + 6-bromo-2,5-dimethyl-2H-indazole (1159511-92-8)

Guidance literature:

6-bromo-5-methyl-1H-indazole; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 3h;

Reference yield:

6-bromo-1,5-dimethyl-1H-indazole (1159511-83-7) → [5-(1,5-dimethyl-1H-indazol-6-yl)(2-thienyl)]-N-(2-fluorophenyl)carboxamide (1361379-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 90 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

With potassium acetate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water;

upstream raw materials:

6-bromo-5-methyl-1H-indazole

methyl iodide

Downstream raw materials:

[5-(1,5-dimethyl-1H-indazol-6-yl)(2-thienyl)]-N-(2-fluorophenyl)carboxamide

Refernces