2-Methylamino-5-chloro-2`-fluorobenzophenone

Base Information

• Chemical Name: 2-Methylamino-5-chloro-2`-fluorobenzophenone
• CAS No.: 1548-36-3
• Molecular Formula: C14H11ClFNO
• Molecular Weight: 263.69500
• Hs Code.: 2922399090
• Mol file: 1548-36-3.mol

Synonyms:(5-Chloro-2-(methylamino)phenyl)(2-fluorophenyl)methanone; 5-Chlor-2'-fluor-2-methylaminobenzophenon; 5-Chlor-2'-flur-2-methylamino-benzophenon; 2-Methylamino-5-chlor-2'-fluor-benzophenon; 2-Methylamino-5-chloro-2'-fluorobenzophenone

Chemical Property of 2-Methylamino-5-chloro-2`-fluorobenzophenone

Chemical Property:

• Melting Point: 119-120 °C
• Boiling Point: 429.2±45.0 °C(Predicted)
• PKA: 1.73±0.12(Predicted)
• PSA: 29.10000
• Density: 1.297±0.06 g/cm3(Predicted)
• LogP: 3.82480
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(5-Chloro-2-(methylamino)phenyl)(2-fluorophenyl)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methylamino-5-chloro-2`-fluorobenzophenone

There total 5 articles about 2-Methylamino-5-chloro-2`-fluorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

dimethyl sulfate (77-78-1) + 2-amino-5-chloro-2'-fluorobenzophenone (784-38-3) → 2-chloroacridin-9(10H)-one (7497-52-1) + (5-chloro-2-(methylamino)phenyl)(2-fluorophenyl)methanone (1548-36-3)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In tetrahydrofuran; at 60 ℃; for 2h;

DOI:10.1055/s-1981-29477

Reference yield: 64.0%

trimethylsilyl iodide (16029-98-4) + C14H10ClFNO(1+)*CH3O4S(1-) (94341-60-3) → (5-chloro-2-(methylamino)phenyl)(2-fluorophenyl)methanone (1548-36-3)

Guidance literature:

In chloroform; for 12h; Ambient temperature;

Reference yield:

C14H9ClFNO → (5-chloro-2-(methylamino)phenyl)(2-fluorophenyl)methanone (1548-36-3)

Guidance literature:

With sodium cyanoborohydride; In methanol; at 20 ℃; for 4h;

DOI:10.1002/adsc.201701579

upstream raw materials:

trimethylsilyl iodide

C₁₄H₁₀ClFNO⁽¹⁺⁾*CH₃O₄S^(1-)

dimethyl sulfate

2-amino-5-chloro-2'-fluorobenzophenone

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