7497-52-1

Basic information

• Product Name: 2-CHLOROACRIDIN-9(10H)-ONE
• Synonyms: 2-CHLOROACRIDIN-9(10H)-ONE;2-Chloroacridone;NSC 406615
• CAS NO: 7497-52-1
• Molecular Formula: C₁₃H₈ClNO
• Molecular Weight: 229.66
• Mol File: 7497-52-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 394.2°Cat760mmHg
• Flash Point: 192.2°C
• Appearance: white powder
• Density: 1.346g/cm³
• Vapor Pressure: 2.01E-06mmHg at 25°C
• Refractive Index: 1.649
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-CHLOROACRIDIN-9(10H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROACRIDIN-9(10H)-ONE(7497-52-1)
• EPA Substance Registry System: 2-CHLOROACRIDIN-9(10H)-ONE(7497-52-1)

Safety Data

• Hazardous Substances Data: 7497-52-1(Hazardous Substances Data)

Usage

Uses

2-Chloroacridin-9(10H)-one is a fluorescent molecule formed from the hydrolysis of oxazepam in urine. Acridone analogs that possesses in vitro anticancer activity Ehrlich Ascites Carcinoma (EAC) cells.

InChI:InChI=1/C13H8ClNO/c14-8-5-6-12-10(7-8)13(16)9-3-1-2-4-11(9)15-12/h1-7H,(H,15,16)

Upstream product

• 439-14-5 diazepam 
• 77-78-1 dimethyl sulfate 
• 784-38-3 2-amino-5-chloro-2'-fluorobenzophenone 

Downstream Products

• 6321-64-8 2-chloro-10-phenylacridin-9(10H)-one 
• 1236-84-6 9-benzylthio-2-chloro-acridine 
• 23250-39-7 2-chloro-acridin-9-ylamine 
• 1019-14-3 2,9-dichloroacridine 
• 7497-56-5 4-(2-chloro-acridin-9-yl)-N,N-dimethyl-aniline 

Relevant articles and documents

Isolation and structure elucidation of novel products of the acidic degradation of diazepam

The acidic degradation of diazepam in methanolic aqueous solution has been investigated. Apart from the known degradation products, 2-(N-methylamino)- 5-chlorobenzophenone and glycine, produced by the hydrolytic cleavage of the benzodiazepinone ring, five novel products were isolated and fully characterized by their spectroscopic features and independent synthesis. Substituted 2-amino-3,5-dichlorobenzophenones and 2,4-dichloroacridinones were found, the formation of which in the reaction media is mechanistically intriguing. The rule of these unexpected products in accelerated studies of diazepam stability is discussed.