PF-03814735

Base Information

Chemical Name:PF-03814735
CAS No.:942487-16-3
Molecular Formula:C₂₃H₂₅F₃N₆O₂
Molecular Weight:474.486
Hs Code.:
Mol file:942487-16-3.mol

Synonyms:N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]acetamide;

Suppliers and Price of PF-03814735

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
PF 03814735
10mg
$ 579.00

TRC
PF03814735
50mg
$ 570.00

Tocris
PF03814735 ≥98%(HPLC)
50
$ 872.00

Tocris
PF03814735 ≥98%(HPLC)
10
$ 208.00

Sigma-Aldrich
PF-03814735 ≥98% (HPLC)
5mg
$ 101.00

Sigma-Aldrich
PF-03814735 ≥98% (HPLC)
25mg
$ 399.00

Medical Isotopes, Inc.
PF03814735
10 mg
$ 775.00

Medical Isotopes, Inc.
PF03814735
5 mg
$ 650.00

DC Chemicals
PF-03814735 >98%
100 mg
$ 600.00

Crysdot
PF-03814735 98+%
50mg
$ 500.00

Total 19 raw suppliers

Chemical Property of PF-03814735

Chemical Property:

PKA:15.02±0.46(Predicted)
PSA：99.25000
Density:1.443
LogP:4.53250
Storage Temp.:?20°C
Solubility.:DMSO: soluble20mg/mL, clear

Purity/Quality:

97% ^*data from raw suppliers

PF 03814735 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. PF-03814735 is a reversible inhibitor of both Aurora A and B kinases with IC50 values of 0.8 and 5 nM, respectively, in in vitro activity assays. PF-03814735 also inhibits the kinases FLT1, FAK, TrkA, Met, and FGFR1 with IC50 values of 10, 22, 30, 100, and 100 nM, respectively. PF-03814735 inhibits cell proliferation of HCT116, HL-60, A549, and H125 tumor cell lines with IC50 values ranging from 42-150 nM and shows in vivo efficacy in an HCT116 tumor xenograft mouse model. PF-03814735 has been shown to be particularly sensitive towards inhibiting the growth of small cell lung cancer cell lines and other tumors driven by the Myc family genes.
Uses PF 03814735 is an orally bioavailable small molecule aurora kinase inhibitor that plays a key role in the regulation of mitosis. PF 03814735 is a anticancer agent used for cancer therapy. The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. PF-03814735 is a reversible inhibitor of both Aurora A and B kinases with IC50 values of 0.8 and 5 nM, respectively, in in vitro activity assays. PF-03814735 also inhibits the kinases FLT1, FAK, TrkA, Met, and FGFR1 with IC50 values of 10, 22, 30, 100, and 100 nM, respectively. PF-03814735 inhibits cell proliferation of HCT-116, HL-60, A549, and H125 tumor cell lines with IC50 values ranging from 42-150 nM and shows in vivo efficacy in an HCT-116 tumor xenograft mouse model. PF-03814735 has been shown to be particularly sensitive towards inhibiting the growth of small cell lung cancer cell lines and other tumors driven by the Myc family genes.[Cayman Chemical]

Technology Process of PF-03814735

There total 1 articles about PF-03814735 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%