Aurora Kinase Inhibitors
Aurora kinase inhibitors are a class of compounds that target Aurora kinases, a family of serine/threonine kinases crucial for regulating various aspects of mitosis. There are three main members of the Aurora kinase family: Aurora A, Aurora B, and Aurora C. These kinases play pivotal roles in spindle assembly, chromosome segregation, and cytokinesis during cell division. Aurora kinase inhibitors work by binding to the ATP-binding pocket of these enzymes, thereby inhibiting their catalytic activity. By disrupting the proper function of Aurora kinases, these inhibitors induce mitotic defects and eventually lead to cell cycle arrest or apoptosis in rapidly dividing cells.
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