(2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoicacid

Base Information

Chemical Name:(2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoicacid
CAS No.:1180676-32-7
Molecular Formula:C17H15ClO2
Molecular Weight:286.758
Hs Code.:
Mol file:1180676-32-7.mol

Synonyms:(2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoicacid;PS 48;(Z)-5-(4-Chlorophenyl)-3-phenylpent-2-enoic acid

Suppliers and Price of (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoicacid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
PS 48
10mg
$ 366.00

Usbiological
PS 48
10mg
$ 355.00

TRC
PS48
50mg
$ 280.00

TRC
PS48
10mg
$ 85.00

Sigma-Aldrich
PS48 ≥98% (HPLC)
5mg
$ 113.00

Sigma-Aldrich
PS48 ≥98% (HPLC)
25mg
$ 451.00

DC Chemicals
PS48 >98%
1 g
$ 1700.00

DC Chemicals
PS48 >98%
100 mg
$ 550.00

Biosynth Carbosynth
PS 48
10 mg
$ 200.00

Biosynth Carbosynth
PS 48
5 mg
$ 130.00

Total 21 raw suppliers

Chemical Property of (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoicacid

Chemical Property:

Melting Point:114-115℃
Boiling Point:444.1±24.0 °C(Predicted)
PKA:4.55±0.10(Predicted)
PSA：37.30000
Density:1.225±0.06 g/cm3(Predicted)
LogP:4.44080
Storage Temp.:Store at +4°C
Solubility.:DMSO: >20mg/mL

Purity/Quality:

99%, ^*data from raw suppliers

PS 48 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses PS 48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator.

Technology Process of (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoicacid

There total 3 articles about (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1180676-62-3
ethyl 5-(4-chlorophenyl)-3-phenylpent-2-enoate

: 1180676-32-7
PS 48

Guidance literature:: ethyl 5-(4-chlorophenyl)-3-phenylpent-2-enoate; With sodium hydroxide; In ethanol; water; for 4h; Reflux;

With hydrogenchloride; In ethanol; water; pH=2;
DOI:10.1021/jm9001499

Reference yield:

: 956-04-7
3-(4-chlorophenyl)-1-phenylprop-2-en-1-one

: 1180676-32-7
PS 48

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate / toluene / 17 h / 70 °C / Darkness

2.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: 4 h / 80 °C

3.1: sodium hydroxide / ethanol / 4 h / 20 °C

3.2: pH 2

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; sodium hydride; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; toluene; mineral oil;

Reference yield:

: 5739-39-9
3-(4-chlorophenyl)-1-phenylpropan-1-one

: 1180676-32-7
PS 48

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 1 h / 20 °C / Inert atmosphere

1.2: 4 h / 80 °C

2.1: sodium hydroxide / ethanol / 4 h / 20 °C

2.2: pH 2

With sodium hydride; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; mineral oil;