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956-04-7

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956-04-7 Usage

Definition

ChEBI: A member of the class of chalcones that is trans-chalcone substituted by a chloro group at position 4.

Synthesis Reference(s)

Tetrahedron Letters, 28, p. 4541, 1987 DOI: 10.1016/S0040-4039(00)96558-4

General Description

4-Chlorochalcone is a chalcone derivative. Its crystals exhibit monoclinic system with space group P21/c. It can undergo conjugate addition reaction with pyrrole in the presence of AlKIT-5 (mesoporous 3D aluminosilicate catalyst) to form the corresponding C2-alkylated pyrrole derivatives.

Check Digit Verification of cas no

The CAS Registry Mumber 956-04-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,5 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 956-04:
(5*9)+(4*5)+(3*6)+(2*0)+(1*4)=87
87 % 10 = 7
So 956-04-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H11ClO/c16-14-9-6-12(7-10-14)8-11-15(17)13-4-2-1-3-5-13/h1-11H/b11-8+

956-04-7 Well-known Company Product Price

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  • Alfa Aesar

  • (A15978)  4-Chlorochalcone, 98+%   

  • 956-04-7

  • 10g

  • 382.0CNY

  • Detail
  • Alfa Aesar

  • (A15978)  4-Chlorochalcone, 98+%   

  • 956-04-7

  • 50g

  • 1395.0CNY

  • Detail
  • Alfa Aesar

  • (A15978)  4-Chlorochalcone, 98+%   

  • 956-04-7

  • 250g

  • 5748.0CNY

  • Detail

956-04-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-chlorochalcone

1.2 Other means of identification

Product number -
Other names 4-CHLOROBENZYLIDENE ACETOPHENONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:956-04-7 SDS

956-04-7Relevant articles and documents

Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new pyrazolylthiazole derivatives

Madni, Murtaza,Hameed, Shahid,Ahmed, Muhammad N.,Tahir, Muhammad N.,Al-Masoudi, Najim A.,Pannecouque, Christophe

, p. 2653 - 2665 (2017)

The development of new HIV-1 non-nucleoside reverse transcriptase inhibitors offers the possibility of generating novel structures of increased potency. Based on the bioisosteric principle, new series of N′-benzylidene-2-(5-(4-chlorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)thiazole-4-carbohydrazide schiff bases 5a–x containing 1,3-thiazole clubbed with 2-pyrazoline was synthesized and characterized by spectroscopic techniques. The structure of the synthesized compounds was unambiguously confirmed by single-crystal X-ray diffraction analysis of compound 5k. All the new analogs were evaluated in vitro for antiviral activity against the replication of HIV-1 and HIV-2 in MT4 cells using MTT assay. The results showed that only compounds 5n, and 5r possess potent activity against HIV-1 replication (IC50 = 0.50, 0.45 μM, SI = 3 and 5), respectively. None of the compounds are active against HIV-2. Furthermore, compounds 5a, 5i, 5n, and 5r were evaluated for their antiproliferative activity against two solid tumor-derived cell lines consisting MCF-7 (breast cancer) and Hep-G2 (human hepatocarcinoma).

A new method for the synthesis of chalcone derivatives promoted by PPh3/I2under non-alkaline conditions

Xue, Kangsheng,Sun, Guoxiang,Zhang, Yanzhi,Chen, Xubing,Zhou, Yang,Hou, Jinjun,Long, Huali,Zhang, Zijia,Lei, Min,Wu, Wanying

supporting information, p. 625 - 634 (2020/11/23)

A straightforward and general method has been developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in the presence of PPh3/I2 in 1,4-dioxane under reflux temperatures. With the condensation of the aromatic ketone and aldehyde occurring at non-strongly alkaline conditions, our proposed method significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions.

Chemoselective reduction of ?,¢-unsaturated carbonyl and carboxylic compounds by hydrogen iodide

Matsumoto, Shoji,Marumoto, Hayato,Akazome, Motohiro,Otani, Yasuhiko,Kaiho, Tatsuo

, p. 590 - 599 (2021/03/29)

The selective reduction of ?,¢-unsaturated carbonyl compounds was achieved to produce saturated carbonyl compounds with aqueous HI solution. The introduction of an aryl group at an ? or ¢ position efficiently facilitated the reduction with good yield. The reaction was applicable to compounds bearing carboxylic acids and halogen atoms. Through the investigation of the reaction mechanism, it was found that Michael-type addition of iodide occurred to produce ¢-iodo compounds followed by the reduction of C-I bond via anionic and radical paths.

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