6-fluoro-N-(4-fluorobenzyl)quinazolin-4-amine

Base Information

Chemical Name:6-fluoro-N-(4-fluorobenzyl)quinazolin-4-amine
CAS No.:1262888-28-7
Molecular Formula:C15H11F2N3
Molecular Weight:271.269
Hs Code.:2933990090
Mol file:1262888-28-7.mol

Synonyms:SPAUTIN-1, AUTOPHAGY INHIBITOR (6-FLUORO-N-(4-FLUOROBENZYL)QUINOZALINE-4-AMINE);6-FLUORO-N-(4-FLUOROBENZYL)QUINAZOLIN-4-AMINE;

Suppliers and Price of 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Spautin 1
10mg
$ 389.00

TRC
Spautin-1
250mg
$ 1955.00

TRC
Spautin-1
10mg
$ 115.00

TRC
Spautin-1
50mg
$ 495.00

Tocris
Spautin1 ≥98%(HPLC)
50
$ 610.00

Tocris
Spautin1 ≥98%(HPLC)
10
$ 150.00

TCI Chemical
Spautin-1
10MG
$ 196.00

TCI Chemical
Spautin-1
50MG
$ 679.00

SynQuest Laboratories
6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine 98.0%
100 mg
$ 528.00

SynQuest Laboratories
6-Fluoro-N-(4-fluorobenzyl)quinazolin-4-amine 98.0%
50 mg
$ 370.00

Total 27 raw suppliers

Chemical Property of 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-amine

Chemical Property:

Melting Point:211 °C
Boiling Point:419.6±40.0 °C(Predicted)
PKA:5.75±0.50(Predicted)
PSA：37.81000
Density:1.366±0.06 g/cm3(Predicted)
LogP:3.59310
Storage Temp.:2-8°C
Solubility.:DMSO: soluble15mg/mL (clear solution)

Purity/Quality:

99%, ^*data from raw suppliers

Spautin 1 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 22-41
Safety Statements: 26-39

MSDS Files:: SDS file from LookChem

Useful:

Description Spautin-1 (1262888-28-7) is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes.1?Deranges dengue virion maturation.2?Spautin-1 inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells.3?Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency.4?Cell permeable.
Uses Spautin-1 is a potent pharmacological autophagy inhibitor that promotes UVB-induced tumorigenesis. It is also a small-molecule drug that modulate autophagic pathways in different types of cancer. Spautin-1 has been used as an autophagy inhibitor:to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse modelto evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicinto study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay

Technology Process of 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-amine

There total 4 articles about 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 446-08-2
2-amino-5-fluorobenzoic acid

: 1262888-28-7
N-(4-fluorobenzyl)-6-fluoroquinazoline-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / benzene / 4 h / Reflux

1.2: 20 °C

2.1: N,N-dimethyl-formamide / 2 h / 170 °C / Autoclave

3.1: trichlorophosphate; phosphorus pentachloride / 2 h / Heating

4.1: triethylamine / N,N-dimethyl-formamide / 4 h / Reflux

With thionyl chloride; phosphorus pentachloride; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide; benzene;
DOI:10.3390/molecules22020188

Reference yield:

: 16499-56-2
6-fluoro-3,4-dihydroquinazolin-4-one

: 1262888-28-7
N-(4-fluorobenzyl)-6-fluoroquinazoline-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate; phosphorus pentachloride / 2 h / Heating

2: triethylamine / N,N-dimethyl-formamide / 4 h / Reflux

With phosphorus pentachloride; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.3390/molecules22020188

Reference yield:

: 63069-49-8
2-amino-5-fluorobenzamide

: 1262888-28-7
N-(4-fluorobenzyl)-6-fluoroquinazoline-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 2 h / 170 °C / Autoclave

2: trichlorophosphate; phosphorus pentachloride / 2 h / Heating

3: triethylamine / N,N-dimethyl-formamide / 4 h / Reflux

With phosphorus pentachloride; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.3390/molecules22020188