Technology Process of 4-FLUORO-2-NITRO-ALPHA-OXO-BENZENE PROPANOIC ACID ETHYL ESTER
There total 1 articles about 4-FLUORO-2-NITRO-ALPHA-OXO-BENZENE PROPANOIC ACID ETHYL ESTER which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-nitro-4-fluorotoluene;
With
sodium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 0.5h;
oxalic acid diethyl ester;
In
tetrahydrofuran;
at 40 ℃;
for 24h;
- Guidance literature:
-
With
iron;
In
ethanol; acetic acid;
for 3.5h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: iron; acetic acid / ethanol / 3.5 h / Heating / reflux
2.1: dmap; triethylamine / dichloromethane / 20 °C
3.1: diisobutylaluminium hydride / toluene / 2.5 h / -78 - -20 °C
3.2: 0.17 h / 20 °C
4.1: carbon tetrabromide; triphenylphosphine / benzene / 2 h / 0 - 20 °C
5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
6.1: morpholine / tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 5 h / 20 °C
With
morpholine; dmap; carbon tetrabromide; iron; diisobutylaluminium hydride; caesium carbonate; acetic acid; triethylamine; triphenylphosphine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
