Carbamic acid, [3-[4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl]-2-propynyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [3-[4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl]-2-propynyl]-, 1,1-dimethylethyl ester
CAS No.:869366-70-1
Molecular Formula:C22H21ClFNO4
Molecular Weight:417.864
Hs Code.:2924299090
Mol file:869366-70-1.mol

Synonyms:tert-Butyl (3-(4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl)prop-2-yn-1-yl)carbamate; tert-Butyl (3-(4-chloro-2-(2-fluoro-6-methoxybenzoyl)-phenyl)prop-2-yn-1-yl)carbamate; tert-Butyl 3-(4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl)prop-2-ynylcarbamate; Carbamic acid, [3-[4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl]-2-propynyl]-, 1,1-dimethylethyl ester

Suppliers and Price of Carbamic acid, [3-[4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl]-2-propynyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl (3-(4-chloro-2-(2-fluoro-6-methoxybenzoyl)-phenyl)prop-2-yn-1-yl)carbamate 95+%
1g
$ 1647.00

Matrix Scientific
tert-Butyl (3-(4-chloro-2-(2-fluoro-6-methoxybenzoyl)-phenyl)prop-2-yn-1-yl)carbamate 95+%
250mg
$ 742.00

Crysdot
tert-Butyl(3-(4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl)prop-2-yn-1-yl)carbamate 95+%
1g
$ 772.00

American Custom Chemicals Corporation
TERT-BUTYL-(3-(4-CHLORO-2-(2-FLUORO-6-METHOXYBENZOYL)PHENYL)PROP-2-YN-1-YL)CARBAMATE 95.00%
5MG
$ 498.16

AK Scientific
tert-Butyl(3-(4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl)prop-2-yn-1-yl)carbamate
250mg
$ 1051.00

Total 6 raw suppliers

Chemical Property of Carbamic acid, [3-[4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl]-2-propynyl]-, 1,1-dimethylethyl ester

Chemical Property:

PSA：64.63000
LogP:4.98580
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl (3-(4-chloro-2-(2-fluoro-6-methoxybenzoyl)-phenyl)prop-2-yn-1-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Carbamic acid, [3-[4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl]-2-propynyl]-, 1,1-dimethylethyl ester

There total 6 articles about Carbamic acid, [3-[4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl]-2-propynyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1233025-91-6
(5-chloro-2-iodophenyl)(2-fluoro-6-methoxyphenyl)methanone

: 92136-39-5
N-tert-Butoxycarbonyl-1-amino-3-propyne

: 869366-70-1
tert-butyl {3-[4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl]prop-2-yn-1-yl}carbamate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In dichloromethane; at 0 - 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/ml500409n

Reference yield:

: 28910-83-0
(2-amino-5-chlorophenyl)-(2,6-difluorophenyl)methanone

: 869366-70-1
tert-butyl {3-[4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl]prop-2-yn-1-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water; acetic acid / 0.5 h / 20 - 25 °C

1.2: 1 h / 0 - 5 °C

1.3: 3 h / 0 - 25 °C

2.1: tert-butyl methyl ether; methanol / 3.5 h / 25 - 30 °C

3.1: diethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / cyclohexane / 15 h / 28 - 33 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; tert-butyl methyl ether; cyclohexane; water; acetic acid;

Reference yield:

: 869365-97-9
(5-chloro-2-iodophenyl)(2,6-difluorophenyl)methanone

: 869366-70-1
tert-butyl {3-[4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl]prop-2-yn-1-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: tert-butyl methyl ether; methanol / 3.5 h / 25 - 30 °C

2: diethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / cyclohexane / 15 h / 28 - 33 °C / Inert atmosphere

With copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; tert-butyl methyl ether; cyclohexane;