(5-CHLORO-2-IODOPHENYL)(2-FLUORO-6-METHOXYPHENYL)METHANONE

Base Information

• Chemical Name: (5-CHLORO-2-IODOPHENYL)(2-FLUORO-6-METHOXYPHENYL)METHANONE
• CAS No.: 1233025-91-6
• Molecular Formula: C14H9ClFIO2
• Molecular Weight: 390.58
• Hs Code.: 2914700090
• Mol file: 1233025-91-6.mol

Synonyms:Methanone, (5-chloro-2-iodophenyl)(2-fluoro-6-methoxyphenyl)-

Chemical Property of (5-CHLORO-2-IODOPHENYL)(2-FLUORO-6-METHOXYPHENYL)METHANONE

Chemical Property:

• Boiling Point: 473.8±45.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.699±0.06 g/cm3(Predicted)
• LogP: 4.32330

Purity/Quality:

99%, ^*data from raw suppliers

(5-Chloro-2-iodophenyl)(2-fluoro-6-methoxyphenyl)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-CHLORO-2-IODOPHENYL)(2-FLUORO-6-METHOXYPHENYL)METHANONE

There total 4 articles about (5-CHLORO-2-IODOPHENYL)(2-FLUORO-6-METHOXYPHENYL)METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(2-amino-5-chlorophenyl)(2-fluoro-6-methoxyphenyl)methanone (869365-89-9) → (5-chloro-2-iodophenyl)(2-fluoro-6-methoxyphenyl)methanone (1233025-91-6)

Guidance literature:

(2-amino-5-chlorophenyl)(2-fluoro-6-methoxyphenyl)methanone; With hydrogenchloride; acetic acid; sodium nitrite; In water; at 9 ℃; for 1.5h; Inert atmosphere;

With potassium iodide; In water; ethyl acetate; at 9 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/ml500409n

Reference yield: 68.0%

methanol (67-56-1) + (5-chloro-2-iodophenyl)(2,6-difluorophenyl)methanone (869365-97-9) → (5-chloro-2-iodophenyl)(2-fluoro-6-methoxyphenyl)methanone (1233025-91-6)

Guidance literature:

With sodium; at 60 ℃; for 3h; Inert atmosphere;

Reference yield: 66.0%

(5-chloro-2-iodophenyl)(2,6-difluorophenyl)methanone (869365-97-9) + sodium methylate (124-41-4) → (5-chloro-2-iodophenyl)(2-fluoro-6-methoxyphenyl)methanone (1233025-91-6)

Guidance literature:

In methanol; tert-butyl methyl ether; at 25 - 30 ℃; for 3.5h;

upstream raw materials:

(5-chloro-2-iodophenyl)(2,6-difluorophenyl)methanone

sodium methylate

(2-amino-5-chlorophenyl)-(2,6-difluorophenyl)methanone

(2-amino-5-chlorophenyl)(2-fluoro-6-methoxyphenyl)methanone

Downstream raw materials:

tert-butyl {3-[4-chloro-2-(2-fluoro-6-methoxybenzoyl)phenyl]prop-2-yn-1-yl}carbamate

alisertib

8-chloro-4-[(dimethylamino)methylene]-1-(2-fluoro-6-methoxyphenyl)-3,4-dihydro-5H-2-benzazepin-5-one

4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoate sodium salt

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