tert-butyl 4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate
• CAS No.: 913264-42-3
• Molecular Formula: C15H25N3O3
• Molecular Weight: 295.38
• Hs Code.: 2934999090
• Mol file: 913264-42-3.mol

Synonyms:tert-butyl 4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

Chemical Property:

• PSA: 68.46000
• LogP: 3.24540
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-(3-Isopropyl-[1,2,4]oxadiazol-5-yl)piperidine-1-carboxylic acid tert-butyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-({[(1 E/Z)-N-hydroxy-2-methylpropanimidoyl]amino}carbonyl)piperidine-1-carboxylate (913264-41-2) → tert-butyl 4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (913264-42-3)

Guidance literature:

In 1,4-dioxane; for 18h; Heating / reflux;

Reference yield: 39.5%

isopropyl formate (625-55-8) + N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → tert-butyl 4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (913264-42-3)

Guidance literature:

isopropyl formate; N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid; With 4-methyl-morpholine; In ethyl acetate; at 0 - 20 ℃; for 12h;

With N-hydroxybutyramide; In N,N-dimethyl-formamide; at 110 ℃; for 7h;

Reference yield:

isobutyramide oxime (35613-84-4) + 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate (124443-68-1) → tert-butyl 4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (913264-42-3)

Guidance literature:

isobutyramide oxime; With sodium hydride; In tetrahydrofuran; at 20 - 50 ℃; for 3h; Molecular sieve;

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate; In tetrahydrofuran; for 3h; Reflux;

DOI:10.1021/jm8006867

upstream raw materials:

tert-butyl 4-({[(1 E/Z)-N-hydroxy-2-methylpropanimidoyl]amino}carbonyl)piperidine-1-carboxylate

isobutyramide oxime

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

isopropyl formate

Downstream raw materials:

4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine hydrochloride

4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidine

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