4-(3-ISOPROPYL-1,2,4-OXADIAZOL-5-YL)PIPERIDINE

Base Information

• Chemical Name: 4-(3-ISOPROPYL-1,2,4-OXADIAZOL-5-YL)PIPERIDINE
• CAS No.: 733748-92-0
• Molecular Formula: C10H17 N3 O
• Molecular Weight: 195.264
• Hs Code.: 2934999090
• Mol file: 733748-92-0.mol

Synonyms:3-Isopropyl-5-(piperidin-4-yl)-1,2,4-oxadiazole;4-(3-Isopropyl-1,2,4-oxadiazol-5-yl)piperidine;4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine(SALTDATA: HCl)

Chemical Property of 4-(3-ISOPROPYL-1,2,4-OXADIAZOL-5-YL)PIPERIDINE

Chemical Property:

• Vapor Pressure: 0.000397mmHg at 25°C
• Refractive Index: 1.487
• Boiling Point: 316.9°C at 760 mmHg
• PKA: 9.58±0.10(Predicted)
• Flash Point: 145.5°C
• PSA: 50.95000
• Density: 1.049g/cm³
• LogP: 1.98880
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-(3-Isopropyl-1,2,4-oxadiazol-5-yl)piperidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-ISOPROPYL-1,2,4-OXADIAZOL-5-YL)PIPERIDINE

There total 3 articles about 4-(3-ISOPROPYL-1,2,4-OXADIAZOL-5-YL)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate (913264-42-3) → 4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidine (733748-92-0)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 4h;

Reference yield:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → 4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidine (733748-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine / ethyl acetate / 12 h / 0 - 20 °C

1.2: 7 h / 110 °C

2.1: hydrogenchloride / water; ethyl acetate / 4 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; In water; ethyl acetate;

Reference yield:

→ 4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidine (733748-92-0)

Guidance literature:

upstream raw materials:

tert-butyl 4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

Downstream raw materials:

4-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-6-(4-methanesulfonyl-phenoxy)-pyrimidine-5-carbonitrile

4-(2,5-difluoro-phenylamino)-6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-pyrimidine-5-carbonitrile

4-(2,3-difluoro-phenylamino)-6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-pyrimidine-5-carbonitrile

1-[4-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-6-(4-methanesulfonyl-phenoxy)-pyrimidin-5-yl]-ethanone

Refernces

• 1、 -. "NEW BICYCLIC COMPOUND FOR MODULATING G PROTEIN-COUPLED RECEPTORS". Paragraph 0228-0230. . Retrieved 2013/10/22.