7-Methoxy-2-methylquinolin-4-ol

Base Information

• Chemical Name: 7-Methoxy-2-methylquinolin-4-ol
• CAS No.: 103624-90-4
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.214
• Hs Code.: 2933499090
• European Community (EC) Number: 621-036-9
• ChEMBL ID: CHEMBL1256108
• DSSTox Substance ID: DTXSID60401231
• Mol file: 103624-90-4.mol

Synonyms:7-methoxy-2-methylquinolin-4-ol;103624-90-4;4-Hydroxy-7-methoxy-2-methylquinoline;7-methoxy-2-methyl-1H-quinolin-4-one;7-METHOXY-2-METHYL-4-QUINOLINOL;MFCD00086643;58596-43-3;Oprea1_062333;SCHEMBL3740247;SCHEMBL8139912;CHEMBL1256108;DTXSID60401231;CHEBI:191056;AC2773;AKOS005142056;SB68210;7-Methoxy-2-methylquinolin-4(1H)-one;SY037170;CS-0215573;EN300-262403;A896401;Z3225838956

Chemical Property of 7-Methoxy-2-methylquinolin-4-ol

Chemical Property:

• Vapor Pressure: 0.000239mmHg at 25°C
• Boiling Point: 324.9°C at 760 mmHg
• Flash Point: 150.3°C
• PSA: 42.35000
• Density: 1.153g/cm³
• LogP: 2.25740
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 189.078978594
• Heavy Atom Count: 14
• Complexity: 273

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-7-methoxy-2-methylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)C2=C(N1)C=C(C=C2)OC

Technology Process of 7-Methoxy-2-methylquinolin-4-ol

There total 4 articles about 7-Methoxy-2-methylquinolin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl acetoacetate (141-97-9) + m-Anisidine (536-90-3,918666-97-4) → 7-methoxy-2-methylquinolin-4-ol (103624-90-4)

Guidance literature:

ethyl acetoacetate; m-Anisidine; at 100 ℃; for 16h;

In diphenylether; at 260 ℃;

DOI:10.1021/acs.joc.9b02780

Reference yield:

3-(3-methoxyphenylamino)but-2-enoic acid ethyl ester (33240-22-1) → 7-methoxy-2-methylquinolin-4-ol (103624-90-4)

Guidance literature:

With 1-Chloronaphthalene;

Reference yield:

m-Anisidine (536-90-3,918666-97-4) → 7-methoxy-2-methylquinolin-4-ol (103624-90-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous hydrochloric acid

2: diphenyl ether

With hydrogenchloride; diphenylether;

upstream raw materials:

3-(3-methoxyphenylamino)but-2-enoic acid ethyl ester

ethyl acetoacetate

m-Anisidine

Downstream raw materials:

5-methoxy-2-(3-methyl-1H-pyrazol-5-yl)aniline

(2-acetylamino-4-methoxy-phenyl)-glyoxylic acid

4-chloro-7-methoxy-2-methylquinoline

NSC 13044