MK-1439

Base Information

Chemical Name:MK-1439
CAS No.:1338225-97-0
Molecular Formula:C17H11ClF3N5O3
Molecular Weight:425.754
Hs Code.:
Mol file:1338225-97-0.mol

Synonyms:3-Chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile;MK-1439;3-Chloro-5-[1-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)pyridin-3-yl]oxybenzonitrile;

Suppliers and Price of MK-1439

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Doravirine
1mg
$ 276.00

TRC
Doravirine
5mg
$ 80.00

DC Chemicals
Doravirine(MK-1439) >98%
100 mg
$ 550.00

ChemScene
Doravirine >98.0%
10mg
$ 480.00

ChemScene
Doravirine >98.0%
5mg
$ 288.00

ChemScene
Doravirine >98.0%
2mg
$ 168.00

ChemScene
Doravirine >98.0%
100mg
$ 2520.00

ChemScene
Doravirine >98.0%
50mg
$ 1800.00

Chemenu
3-chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile 98%
100mg
$ 1103.00

Cayman Chemical
Doravirine
10mg
$ 117.00

Total 47 raw suppliers

Chemical Property of MK-1439

Chemical Property:

PSA：105.70000
LogP:2.65458
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly, Heated), Methanol (Slightly, Heated)

Purity/Quality:

99%, ^*data from raw suppliers

Doravirine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Doravirine is a novel non-nucleoside inhibitor of HIV-1 reverse transcriptase with potent activity against wild-type virus.

Technology Process of MK-1439

There total 20 articles about MK-1439 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.3%

: 1338226-05-3
3-chloro-5-((2-oxo-1-((5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile

: 74-88-4
methyl iodide

: 1338225-97-0
3-chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile

Guidance literature:: With potassium carbonate; In 1-methyl-pyrrolidin-2-one; water; at 5 - 10 ℃; for 34h; Solvent; Reagent/catalyst; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.6b00163

Reference yield: 46.0%

: 1613307-25-7
3-chloro-5-((1-((1-(2-methoxypropan-2-yl)-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile

: 1338225-97-0
3-chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 1h;

Reference yield:

: 1613307-27-9
ethyl 2-(3-chloro-5-cyanophenoxy)acetate

: 1338225-97-0
3-chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium 2-methylbutan-2-olate / toluene

1.2: 0.23 h / -10 - 10 °C

2.1: ammonia / methanol; toluene / 18 h / 60 °C

3.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one; tert-Amyl alcohol / 22 h / 20 °C / Large scale

With ammonia; potassium 2-methylbutan-2-olate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; methanol; tert-Amyl alcohol; toluene;