2-(5-methoxy-1H-indol-3-yl)-2-oxoacetamide

Base Information

• Chemical Name: 2-(5-methoxy-1H-indol-3-yl)-2-oxoacetamide
• CAS No.: 52055-22-8
• Molecular Formula: C11H10N2O3
• Molecular Weight: 218.212
• Hs Code.: 2924199090
• Mol file: 52055-22-8.mol

Synonyms:5-Methoxyindole-3-glyoxylamide;

Chemical Property of 2-(5-methoxy-1H-indol-3-yl)-2-oxoacetamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 475.803°C at 760 mmHg
• Flash Point: 241.557°C
• PSA: 85.18000
• Density: 1.379g/cm³
• LogP: 1.54480
• Storage Temp.: 2-8°C
• Solubility.: Dimethylsulfoxide, Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

5-Methoxyindole-3-glyoxylamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate in the preparation of Serotonin derivatives.

Technology Process of 2-(5-methoxy-1H-indol-3-yl)-2-oxoacetamide

There total 3 articles about 2-(5-methoxy-1H-indol-3-yl)-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(5-methoxy-1H-indol-3-yl)oxoacetyl chloride (2426-19-9) → 2-(5-methoxy-1H-indol-3-yl)-2-oxo-acetamide (52055-22-8)

Guidance literature:

With ammonia; In toluene;

Reference yield:

5-methoxylindole (1006-94-6) → 2-(5-methoxy-1H-indol-3-yl)-2-oxo-acetamide (52055-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 6 h / Heating

2: NH₃ / dioxane / 8 h / 20 °C

With ammonia; In 1,4-dioxane; diethyl ether;

DOI:10.1021/ol026729p

Reference yield:

→ 2-(5-methoxy-1H-indol-3-yl)-2-oxo-acetamide (52055-22-8)

Guidance literature:

5-Methoxy-indol-3-glyoxylchlorid, wss. NH3 unter Kuehlung;

upstream raw materials:

(5-methoxy-1H-indol-3-yl)oxoacetyl chloride

5-methoxylindole

Downstream raw materials:

2-(5-methoxyindol-3-yl)ethylamine

5-methoxytryptamine-α,α,β,β-d₄

Refernces

• 1、 -. "ARYL HYDROCARBON RECEPTOR MODULATOR". Paragraph 0076; 0078. . Retrieved 2019/10/20.
• 2、 Wu, Tom Y. H.,Schulte, Peter G.. "A versatile linkage strategy for solid-phase synthesis of N,N-dimethyltryptamines and β-carbolines". . p. 4033 - 4035. Retrieved 2007/10/03.