Benzenepropanenitrile, 2-fluoro-

Base Information

• Chemical Name: Benzenepropanenitrile, 2-fluoro-
• CAS No.: 877149-83-2
• Molecular Formula: C9H8FN
• Molecular Weight: 149.168
• Hs Code.: 2926909090
• Mol file: 877149-83-2.mol

Synonyms:2-fluoroBenzenepropanenitrile;3-(2-fluorophenyl)propanenitrile;Benzenepropanenitrile, 2-fluoro-

Chemical Property of Benzenepropanenitrile, 2-fluoro-

Chemical Property:

• PSA: 23.79000
• LogP: 2.28188

Purity/Quality:

97% ^*data from raw suppliers

3-(2-Fluorophenyl)-propionitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanenitrile, 2-fluoro-

There total 8 articles about Benzenepropanenitrile, 2-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-fluorobenzyl alcohol (446-51-5) + acetonitrile (75-05-8,26809-02-9) → 3-(2-fluorophenyl)propanenitrile (877149-83-2)

Guidance literature:

2-fluorobenzyl alcohol; acetonitrile; With caesium carbonate; at 180 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; at 180 ℃; for 0.666667h; Microwave irradiation; Inert atmosphere;

DOI:10.1021/ol2015972

Reference yield:

3-(2-fluoro-phenyl)acrylonitrile (877149-82-1) → 3-(2-fluorophenyl)propanenitrile (877149-83-2)

Guidance literature:

3-(2-fluoro-phenyl)acrylonitrile; With magnesium; In methanol; at 0 - 20 ℃;

With hydrogenchloride; In water;

Reference yield:

(E)-3-(2'-fluorophenyl)-2-propenenitrile (91319-60-7) → 3-(2-fluorophenyl)propanenitrile (877149-83-2)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 ℃; for 24h;

upstream raw materials:

potassium cyanide

2-fluorobenzeneethanol methanesulfonate (ester)

2-(2-fluorophenyl)ethanol

3-(2-fluoro-phenyl)acrylonitrile

Downstream raw materials:

3-(2-fluorophenyl)propionic acid

3-(2-fluorophenyl)propan-1-ol

ethyl 3-(2-fluorophenyl)propionate