(R)-3-Methylmorpholine hydrochloride

Base Information

• Chemical Name: (R)-3-Methylmorpholine hydrochloride
• CAS No.: 953780-78-4
• Molecular Formula: C5H12ClNO
• Molecular Weight: 137.609
• Hs Code.: 2934999090
• Mol file: 953780-78-4.mol

Synonyms:(R)-3-Methylmorpholine hydrochloride

Chemical Property of (R)-3-Methylmorpholine hydrochloride

Chemical Property:

• Melting Point: 123.0 to 127.0 °C
• PSA: 21.26000
• LogP: 1.12550
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-3-Methylmorpholine Hydrochloride >98.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (3R)-3-Methylmorpholine Hydrochloride is used in the discovery studies of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally active GSK-3β inhibitors for Alzheimer''s disease

Technology Process of (R)-3-Methylmorpholine hydrochloride

There total 5 articles about (R)-3-Methylmorpholine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(R)-4-(4-methoxybenzyl)-3-methylmorpholine (954133-47-2) → (3R)-3-methylmorpholine hydrochloride (953780-78-4,192661-47-5)

Guidance literature:

(R)-4-(4-methoxybenzyl)-3-methylmorpholine; With carbonochloridic acid 1-chloro-ethyl ester; In 1,2-dichloro-ethane; at 80 ℃; for 6h;

With methanol; at 80 ℃; for 1h;

Reference yield:

(3R)-3-methyl-4-(phenylmethyl)morpholine (74571-98-5) → (3R)-3-methylmorpholine hydrochloride (953780-78-4,192661-47-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; water; at 20 ℃;

Reference yield:

(5R)-5-methyl-4-(phenylmethyl)-3-morpholinone (120800-86-4) → (3R)-3-methylmorpholine hydrochloride (953780-78-4,192661-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0 - 60 °C

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium bis(2-methoxyethoxy)aluminium dihydride; In methanol; water; toluene;

DOI:10.1021/jm101527u

upstream raw materials:

(R)-4-(4-methoxybenzyl)-3-methylmorpholine

(3R)-3-methyl-4-(phenylmethyl)morpholine

(5R)-5-methyl-4-(phenylmethyl)-3-morpholinone

(R)-4-(4-methoxybenzyl)-5-methylmorpholin-3-one

Downstream raw materials:

((1R,2S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopropyl)((R)-3-methylmorpholino)methanone

((1S,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopropyl)((R)-3-methylmorpholino)methanone

((7R,8R)-8-(5-(4-bromophenyl)-1H-imidazol-2-yl)-1,4-dioxaspiro[4.4]nonan-7-yl)((R)-3-methylmorpholino)methanone

((1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutyl)((R)-3-methylmorpholino)methanone