(R)-N-Boc-1-(5-(trifluoroMethyl)pyridin-2-yl)pyrrolidin-3-aMine

Base Information

Chemical Name:(R)-N-Boc-1-(5-(trifluoroMethyl)pyridin-2-yl)pyrrolidin-3-aMine
CAS No.:717906-56-4
Molecular Formula:C15H20F3N3O2
Molecular Weight:331.33
Hs Code.:
Mol file:717906-56-4.mol

Synonyms:tert-butyl {(3R)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl}carbamate;(R)-N-BOC-1-(5-(TRIFLUOROMETHYL)PYRIDIN-2-YL)PYRROLIDIN-3-AMINE;

Suppliers and Price of (R)-N-Boc-1-(5-(trifluoroMethyl)pyridin-2-yl)pyrrolidin-3-aMine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (R)-N-Boc-1-(5-(trifluoroMethyl)pyridin-2-yl)pyrrolidin-3-aMine

Chemical Property:

Boiling Point:433.3±45.0 °C(Predicted)
PKA:12.17±0.20(Predicted)
PSA：54.46000
Density:1.26±0.1 g/cm3(Predicted)
LogP:3.65970

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-N-Boc-1-(5-(trifluoroMethyl)pyridin-2-yl)pyrrolidin-3-aMine

There total 1 articles about (R)-N-Boc-1-(5-(trifluoroMethyl)pyridin-2-yl)pyrrolidin-3-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 122536-77-0,140629-77-2
3-N-tert-butoxycarbonyl-3-(R)-aminopyrrolidine

: 717906-56-4
[(R)-1-(5-trifluoromethylpyridin-2-yl)pyrrolidin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 7h;
DOI:10.1016/j.bmcl.2006.03.030

Reference yield:

: 717906-56-4
[(R)-1-(5-trifluoromethylpyridin-2-yl)pyrrolidin-3-yl]-carbamic acid tert-butyl ester

: 54495-51-1
(E)-3-(2-pyridyl)acrylic acid

: (2E)-3-(pyridin-2-yl)-N-{1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl}acrylamide ditrifluoroacetate

Guidance literature:: [(R)-1-(5-trifluoromethylpyridin-2-yl)pyrrolidin-3-yl]-carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

(E)-3-(2-pyridyl)acrylic acid; With 1-hydroxy-7-aza-benzotriazole; triethylamine; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 717906-56-4
[(R)-1-(5-trifluoromethylpyridin-2-yl)pyrrolidin-3-yl]-carbamic acid tert-butyl ester

: 501951-42-4
N-(2-bromophenyl)-N'-[((R)-1-(5-trifluoromethyl-2-pyridyl)pyrrolidin-3-yl)]urea

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / dioxane / 2 h / 80 °C

2: 84 percent / diethyl ether

With hydrogenchloride; In 1,4-dioxane; diethyl ether;
DOI:10.1016/j.bmcl.2006.03.030