1H-Pyrazole-3-carboxylic acid, 4-(4-methoxyphenyl)-, ethyl ester

Base Information

• Chemical Name: 1H-Pyrazole-3-carboxylic acid, 4-(4-methoxyphenyl)-, ethyl ester
• CAS No.: 70187-29-0
• Molecular Formula: C13H14N2O3
• Molecular Weight: 246.266
• Mol file: 70187-29-0.mol

Synonyms:4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLICACID ETHYLESTER;1H-PYRAZOLE-3-CARBOXYLIC ACID, 4-(4-METHOXYPHENYL)-, ETHYL ESTER;

Chemical Property of 1H-Pyrazole-3-carboxylic acid, 4-(4-methoxyphenyl)-, ethyl ester

Chemical Property:

• PSA: 64.21000
• LogP: 2.26200

Purity/Quality:

97% ^*data from raw suppliers

4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-3-carboxylic acid, 4-(4-methoxyphenyl)-, ethyl ester

There total 3 articles about 1H-Pyrazole-3-carboxylic acid, 4-(4-methoxyphenyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

diethyl-2-(4-methoxybenzylidene)malonate (6768-23-6) → ethyl 4-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate (70187-29-0)

Guidance literature:

With ethanol; caesium carbonate; at 80 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.tet.2018.04.030

Reference yield: 40.0%

1-(p-methylphenylsulfonyl)-1-diazopropan-2-one (2725-60-2) + diethyl-2-(4-methoxybenzylidene)malonate (6768-23-6) → ethyl 4-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate (70187-29-0)

Guidance literature:

With ethanol; caesium carbonate; at 0 ℃; for 3h;

DOI:10.1016/j.tet.2018.04.030

Reference yield: 29.0%

diazoacetic acid ethyl ester (623-73-4) + 1-methoxy-4-(2-nitro-vinyl)-benzene (3179-10-0) → ethyl 4-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate (70187-29-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 96h;

DOI:10.1039/b915231h

upstream raw materials:

diazoacetic acid ethyl ester

1-methoxy-4-(2-nitro-vinyl)-benzene

1-(p-methylphenylsulfonyl)-1-diazopropan-2-one

diethyl-2-(4-methoxybenzylidene)malonate