Benzeneacetic acid, 4-chloro-.alpha.-forMyl-, ethyl ester

Base Information

• Chemical Name: Benzeneacetic acid, 4-chloro-.alpha.-forMyl-, ethyl ester
• CAS No.: 33691-09-7
• Molecular Formula: C11H11ClO3
• Molecular Weight: 226.66
• Mol file: 33691-09-7.mol

Synonyms:ethyl 2-(4'-chlorophenyl)-2-formylacetate;BENZENEACETIC ACID, 4-CHLORO-.ALPHA.-FORMYL-, ETHYL ESTER;ethyl 2-(4-chlorophenyl)-3-oxopropanoate;ethyl p-chlorophenyl-(α-formyl)acetate;Formyl-[4-chlor-phenyl]-essigsaeure-aethylester;2-(4-chloro-phenyl)-3-oxo-propionic acid ethyl ester;2-(4-Chlor-phenyl)-3-oxo-propionsaeure-aethylester;

Chemical Property of Benzeneacetic acid, 4-chloro-.alpha.-forMyl-, ethyl ester

Chemical Property:

• Melting Point: 49-51℃
• Boiling Point: 143-145℃ (8 Torr)
• PSA: 43.37000
• LogP: 2.18560

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, 4-chloro-.alpha.-forMyl-, ethyl ester

There total 5 articles about Benzeneacetic acid, 4-chloro-.alpha.-forMyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.7%

4-chloro-benzeneacetic acid, ethyl ester (14062-24-9) + formic acid ethyl ester (109-94-4) → ethyl α-formyl-4-chlorophenylacetate (33691-09-7)

Guidance literature:

4-chloro-benzeneacetic acid, ethyl ester; formic acid ethyl ester; With potassium tert-butylate; In tert-butyl methyl ether; at -5 - 10 ℃; for 1.5h; Inert atmosphere; Large scale;

With hydrogenchloride; In tert-butyl methyl ether; water; at 0 - 10 ℃; for 0.5h; pH=1.5; Inert atmosphere; Large scale;

DOI:10.1021/op4002966

Reference yield:

4-chloro-benzeneacetic acid, ethyl ester (14062-24-9) + formic acid ethyl ester (109-94-4) → ethyl α-formyl-4-chlorophenylacetate (33691-09-7) + ethyl 2-(4-chlorophenyl)-3-hydroxyacrylate (95322-54-6)

Guidance literature:

4-chloro-benzeneacetic acid, ethyl ester; formic acid ethyl ester; With potassium tert-butylate; In tert-butyl methyl ether; at 0 ℃; for 3h;

With hydrogenchloride; water; In tert-butyl methyl ether;

Reference yield:

p-chlorophenyl butanoate (7476-81-5) + formic acid ethyl ester (109-94-4) → ethyl α-formyl-4-chlorophenylacetate (33691-09-7)

Guidance literature:

With hydrogenchloride; sodium ethanolate; In diethyl ether;

upstream raw materials:

4-chloro-benzeneacetic acid, ethyl ester

formic acid ethyl ester

4-chlorophenylacetic Acid

p-chlorophenyl butanoate

Downstream raw materials:

3-ethoxy-2-(4-chloro-phenyl)-acrylic acid ethyl ester

7-amino-3-(4-chlorophenyl)-2-hydroxy-1,8-naphthyridine

3-[(E)-Benzyloxyimino]-2-(4-chloro-phenyl)-propionic acid ethyl ester

4-(4-Chloro-phenyl)-2H-isoxazol-5-one