Cyclobutanecarboxylic acid, 3-hydroxy-, trans-

Base Information

• Chemical Name: Cyclobutanecarboxylic acid, 3-hydroxy-, trans-
• CAS No.: 1268521-85-2
• Molecular Formula: C₅H₈O₃
• Molecular Weight: 116.117
• Hs Code.: 2916200090
• Mol file: 1268521-85-2.mol

Synonyms:Cyclobutanecarboxylic acid, 3-hydroxy-, trans-;(1r,3r)-3-hydroxycyclobutane-1-carboxylic acid;trans-3-Hydroxycyclobutanecarboxylic acid

Chemical Property of Cyclobutanecarboxylic acid, 3-hydroxy-, trans-

Chemical Property:

• PSA: 57.53000
• LogP: -0.15810
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

trans-3-Hydroxycyclobutanecarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Cyclobutanecarboxylic acid, 3-hydroxy-, trans-

There total 4 articles about Cyclobutanecarboxylic acid, 3-hydroxy-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methylester of 3-hydroxycyclobutane-1-carboxylic acid (4934-99-0) → cis-3-hydroxycyclobutylcarboxylic acid (194788-10-8,552849-33-9,1268521-85-2)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃;

Reference yield: 81.0%

trans-p-nitrobenzoic acid (3-methoxycarbonylcyclobutyl) ester → (1r,3r)‐3‐hydroxycyclobutane‐1‐carboxylic acid (552849-33-9,1268521-85-2)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; Large scale;

Reference yield:

3-hydroxycyclobutylcarboxylic acid benzyl ester (480449-99-8,128041-58-7) → cis-3-hydroxycyclobutylcarboxylic acid (194788-10-8,552849-33-9,1268521-85-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 2h;

upstream raw materials:

3-hydroxycyclobutylcarboxylic acid benzyl ester

methylester of 3-hydroxycyclobutane-1-carboxylic acid

methyl 3-oxocyclobutanecarboxylate

Downstream raw materials:

3-hydroxy-N-methylcyclobutanecarboxamide

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