4934-99-0

Basic information

• Product Name: Methyl 3-hydroxycyclobuta...
• Synonyms: Methyl 3-hydroxycyclobuta...;Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester;methyl 3-hydroxycyclobutanecarboxylate;3-Hydroxycyclobutanecarboxylic acid methyl ester;Methylester of 3-hydroxycyclobutane-1-carboxylic acid;methyl 3-hydroxycyclobutane-1-carboxylate
• CAS NO: 4934-99-0
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.1418
• Mol File: 4934-99-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 190℃
• Flash Point: 76℃
• Appearance: /
• Density: 1.232
• Storage Temp.: 2-8°C
• PKA: 14.73±0.40(Predicted)
• CAS DataBase Reference: Methyl 3-hydroxycyclobuta...(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-hydroxycyclobuta...(4934-99-0)
• EPA Substance Registry System: Methyl 3-hydroxycyclobuta...(4934-99-0)

Safety Data

• Hazardous Substances Data: 4934-99-0(Hazardous Substances Data)

Usage

General Description

"Methyl 3-hydroxycyclobutane-1-carboxylate is a type of organic chemical compound that falls under the category of cyclobutanes. This chemical, often used for research and manufacturing purposes, is typically obtained in liquid form and is mostly colorless. The respective molecular formula is C6H10O3, demonstrating that it includes carbon, hydrogen, and oxygen elements. As an organic compound, it is commonly used in various chemical reactions during laboratory experiments due to its distinctive properties. Some important parameters to consider while handling this chemical are its boiling point, melting point, density, refractive index, flash point, and storage conditions. As with all chemicals, appropriate safety measures should be taken while handling and storing it."

Upstream product

• 4934-98-9 methylester of 3-benzyloxycyclobutane-1-carboxylic acid 
• 84182-46-7 3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid 
• 4958-02-5 3-(benzyloxy)cyclobutane-1-carboxylic acid 
• 23761-23-1 3-oxocyclobutanecarboxylic acid 
• 695-95-4 methyl 3-oxocyclobutanecarboxylate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 4934-97-8 diisoamyl 3-benzyloxycyclobutane-1,1-dicarboxylate 
• 54166-15-3 diethyl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate 

Downstream Products

• 4935-00-6 methyl 3-bromocyclobutanecarboxylate 
• 4958-03-6 <3-Methoxycarbonyl-cyclobutyl>-benzolsulfonat 
• 112623-19-5 3-(hydroxymethyl)cyclobutanol 
• 344338-13-2 methylester of 3-p-toluenesulfonyloxycyclobutane-1-carboxylic acid 
• 344348-50-1 amide of 3-p-toluenesulfonyloxycyclobutane-1-carboxylic acid 
• 74307-75-8 (1r,3r)-3-aminocyclobutane-1-carboxylic acid 
• 74316-27-1 cis-3-aminocyclobutane-1-carboxylic acid 
• 84182-59-2 hydrochloride of cis-3-aminocyclobutane-1-carboxylic acid 
• 4935-01-7 methyl bicyclo<1.1.0>butane-1-carboxylate 
• 5071-67-0 Bicyclo<1.1.0>butan-1-methyl-(4-nitro-benzoat) 
• 1073477-11-8 [3-[tert-butyl(diphenyl)silyl]oxycyclobutyl]methanol 
• 4934-98-9 methylester of 3-benzyloxycyclobutane-1-carboxylic acid 
• 84182-50-3 methyl (E)-3-benzyloxycyclobutane-1-carboxylate 
• 1034044-68-2 3-{3-[6-{[4-(Trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}cyclobutanol 

Relevant articles and documents

Bicyclobutane carboxylic amide as a cysteine-directed strained electrophile for selective targeting of proteins

Expanding the repertoire of electrophiles with unique reactivity features would facilitate the development of covalent inhibitors with desirable reactivity profiles. We herein introduce bicyclo[1.1.0]butane (BCB) carboxylic amide as a new class of thiol-reactive electrophiles for selective and irreversible inhibition of targeted proteins. We first streamlined the synthetic routes to generate a variety of BCB amides. The strain-driven nucleophilic addition to BCB amides proceeded chemoselectively with cysteine thiols under neutral aqueous conditions, the rate of which was significantly slower than that of acrylamide. This reactivity profile of BCB amide was successfully exploited to develop covalent ligands targeting Bruton's tyrosine kinase (BTK). By tuning BCB amide reactivity and optimizing its disposition on the ligand, we obtained a selective covalent inhibitor of BTK. The in-gel activitybased protein profiling and mass spectrometry-based chemical proteomics revealed that the selected BCB amide had a higher target selectivity for BTK in human cells than did a Michael acceptor probe. Further chemical proteomic study revealed that BTK probes bearing different classes of electrophiles exhibited distinct off-target profiles. This result suggests that incorporation of BCB amide as a cysteine-directed electrophile could expand the capability to develop covalent inhibitors with the desired proteome reactivity profile.

DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES

Provided herein are dihydropyrimidine derivatives which are useful in the treatment of HBV infection or HBV-induced diseases, as well as pharmaceutical or medical applications thereof.

Synthesis method of cis-3-hydroxycyclobutylcarboxylic acid

The invention belongs to the field of organic synthesis, and discloses a synthesis method of cis-3-hydroxycyclobutylcarboxylic acid. The synthesis method comprises the following steps: performing efficient stereoselective reduction on 3-carbonyl-cyclobutanecarboxylate (C1-C6 alkyl ester) into single cis-3-hydroxy-cyclobutanecarboxylate by using a proper reducing agent, and performing a hydrolysisreaction to finally obtain the single cis-3-hydroxy-cyclobutanecarboxylic acid. By the synthesis method, raw materials are easy to obtain, the reaction condition is mild, the stereoselectivity is good, and the yield is relatively high; in addition, post-treatment and purification are easy to operate, and the synthesis method is suitable for industrial scale-up production.