AZD-4547

Base Information

Chemical Name:AZD-4547
CAS No.:1035270-39-3
Molecular Formula:C₂₆H₃₃N₅O₃
Molecular Weight:463.58
Hs Code.:
Mol file:1035270-39-3.mol

Synonyms:AZD-4547

Suppliers and Price of AZD-4547

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
AZD 4547
100mg
$ 2272.00

TRC
AZD4547
100mg
$ 150.00

Medical Isotopes, Inc.
AZD4547
100 mg
$ 2120.00

Matrix Scientific
N-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide 95%
1g
$ 1628.00

Matrix Scientific
N-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide 95%
250mg
$ 556.00

DC Chemicals
AZD4547 >98%
250 mg
$ 500.00

DC Chemicals
AZD4547 >98%
1 g
$ 1200.00

DC Chemicals
AZD4547 >98%
100 mg
$ 250.00

ChemScene
AZD4547 99.68%
100mg
$ 228.00

ChemScene
AZD4547 99.68%
50mg
$ 168.00

Total 42 raw suppliers

Chemical Property of AZD-4547

Chemical Property:

Boiling Point:621.7±55.0 °C(Predicted)
PKA:13.66±0.10(Predicted)
PSA：95.00000
Density:1.189
LogP:4.42880
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

AZD 4547 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description AZD4547 is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3. AZD 4547 is a selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinase with IC50 values of 0.2, 2.5, and 1.8 nM for FGFR1, 2, and 3, respectively. It displays weaker activity against FGFR4 (IC50 = 165 nM), VEGFR2 (IC50 = 24 nM), and a panel of other tyrosine and serine/theronine kinases such as insulin-like growth factor 1 receptor (IC50 = 581 nM), cyclin-dependent kinase 2 (IC50 = >10 μM), and p38 (IC50 = >100 μM). AZD 4547 has demonstrated antiproliferative activity in tumor cell lines expressing deregulated FGFRs (IC50s = 18-281 nM). In an FGFR-driven human tumor xenograft mouse model, oral administration of AZD 4547 at concentrations up to 12.5 mg/kg/day resulted in potent dose-dependent antitumor activity.
Uses AZD4547 is a bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinases. AZD4547 is particularly effective in inhibiting FGFR1, 2, and 3 tyrosine k inases and is under clinical investigation for the treatment of FGFR-dependent tumors.

Technology Process of AZD-4547

There total 13 articles about AZD-4547 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%