cis-2,6-Dimethylpiperazine

Base Information

• Chemical Name: cis-2,6-Dimethylpiperazine
• CAS No.: 21655-48-1
• Molecular Formula: C₆H₁₄N₂
• Molecular Weight: 114.191
• Hs Code.: 29335990
• DSSTox Substance ID: DTXSID301296263
• Nikkaji Number: J837.758H
• Wikidata: Q106902847
• Mol file: 21655-48-1.mol

Synonyms:cis-2,6-Dimethylpiperazine;21655-48-1;(2R,6S)-2,6-dimethylpiperazine;Cis-2,6-dimethyl piperazine;CIS-2,6-DIMETHYL-PIPERAZINE;Piperazine, 2,6-dimethyl-, (2R,6S)-rel-;1013625-96-1;(2S,6R)-2,6-dimethylpiperazine;2,6-Dimethylpiperazine #;2,6-cis-dimethylpiperazine;cis 2,6-dimethylpiperazine;cis-2,6 dimethylpiperazine;cis-3,5-dimethylpiperazine;cis-2,6-dimethyl-piperazin;(cis)2,6-dimethylpiperazine;2,6 cis-dimethyl piperazine;cis-3,5 dimethyl piperazine;cis-3,5-dimethyl piperazine;SCHEMBL63549;(cis)-2,6-dimethylpiperazine;(cis)-3,5-Dimethylpiperazine;(cis)-2,6-dimethyl-piperazine;2,6-(cis)-Dimethyl-piperazine;2alpha,6alpha-Dimethylpiperazine;DTXSID301296263;Piperazine, 2,6-dimethyl-, cis-;(2R,65)-2,6-Dimethylpiperazine;(2R,6S) 2,6-Dimethyl-piperazine;(2R,6S)-2,6-Dimethyl-piperazine;(2S,6R)-2,6-dimethyl-piperazine;MFCD07772435;AKOS006350052;rel-(2R,6S)-2,6-Dimethylpiperazine;AM81381;PS-5344;AC-19708;D2360;EN300-137070;H10755;P10485;Z1203730758

Chemical Property of cis-2,6-Dimethylpiperazine

Chemical Property:

• Vapor Pressure: 2.31mmHg at 25°C
• Melting Point: 108-111 °C(lit.)
• Refractive Index: 1.413
• Boiling Point: 161.147 °C at 760 mmHg
• PKA: 9.38±0.60(Predicted)
• Flash Point: 45 °C
• PSA: 24.06000
• Density: 0.824 g/cm³
• LogP: 0.61380
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Light Sensitive & Hygroscopic
• Water Solubility.: Completely soluble in water
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 114.115698455
• Heavy Atom Count: 8
• Complexity: 64.9

Purity/Quality:

99%, ^*data from raw suppliers

cis-2,6-Dimethylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xi
• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 26-36-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CNCC(N1)C
• Isomeric SMILES: C[C@@H]1CNC[C@@H](N1)C
• Uses: cis-2,6-Dimethylpiperazine is a very versatile reagent used in the preparation of biologically active compounds such as antibacterial agents.

Technology Process of cis-2,6-Dimethylpiperazine

There total 8 articles about cis-2,6-Dimethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(β-hydroxy-isopropyl)-(2-hydroxy-propyl)-amine (115893-42-0) + bis(2-hydroxy-1-methylethyl)amine (2294-46-4) + diisopropanolamine (110-97-4,1335-54-2) → (2S,6S)-2,6-dimethyl-piperazine (402832-69-3) + cis-2,6-dimethylpiperazine (21655-48-1,1013625-96-1) + 2,5-dimethyl-piperazine (2815-34-1,1119702-25-8) + (+)-(2S,5S)-2,5-dimethylpiperazine (59573-44-3)

Guidance literature:

With hydrogen; cobalt; In ammonia; at 200 ℃; for 3h; under 22502.3 Torr;

Reference yield: 62.0%

2-Amino-1-propanol (6168-72-5) → cis-2,6-dimethylpiperazine (21655-48-1,1013625-96-1)

Guidance literature:

With ammonia; hydrogen; nickel;

DOI:10.1002/hlca.19900730409

Reference yield:

propylene glycol (57-55-6,63625-56-9) + 1,2-diaminopropan (78-90-0,10424-38-1) → cis-2,6-dimethylpiperazine (21655-48-1,1013625-96-1) + 2,5-dimethyl-piperazine (2815-34-1,1119702-25-8)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydrogencarbonate; In water; at 140 ℃; for 17h; Overall yield = 90%; Inert atmosphere; Heating;

DOI:10.1002/ejoc.201201099

upstream raw materials:

Acetol acetate

diisopropanolamine

glycerol

2-Amino-1-propanol

Downstream raw materials:

1,4-dibenzoyl-2,6-dimethyl-piperazine

1,2,4,6-Tetramethyl-piperazin

(3S,5R)-3,5-dimethylpiperazine-1-carboxylic acid tert-butyl ester

sparfloxacin

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 21655-48-1 2,6-DIMETHYLPIPERAZINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send