Benzene, 2-chloro-1-ethynyl-4-fluoro-

Base Information

• Chemical Name: Benzene, 2-chloro-1-ethynyl-4-fluoro-
• CAS No.: 1057670-02-6
• Molecular Formula: C8H4ClF
• Molecular Weight: 154.571
• Mol file: 1057670-02-6.mol

Synonyms:Benzene, 2-chloro-1-ethynyl-4-fluoro-

Chemical Property of Benzene, 2-chloro-1-ethynyl-4-fluoro-

Chemical Property:

• PSA: 0.00000
• LogP: 2.46040

Purity/Quality:

98%min ^*data from raw suppliers

2-CHLORO-1-ETHYNYL-4-FLUOROBENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 2-chloro-1-ethynyl-4-fluoro-

There total 1 articles about Benzene, 2-chloro-1-ethynyl-4-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

2-chloro-4-fluorobenzaldehyde (84194-36-5) + dimethyl 1-(1-diazo-2-oxopropyl)phosphonate (90965-06-3) → 2-chloro-1-ethynyl-4-fluorobenzene (1057670-02-6)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 16h;

Reference yield: 88.0%

2-chloro-1-ethynyl-4-fluorobenzene (1057670-02-6) + 4-(2-azido-2-(dibenzo[b,d]thiophen-2-yl)ethyl)piperidine → 1-(2-(4-(2-chloro-4-fluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(dibenzo[b,d]thiophen-2-yl)ethyl)piperidine

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; regioselective reaction;

DOI:10.1016/j.bmcl.2016.04.015

Reference yield: 85.0%

2-chloro-1-ethynyl-4-fluorobenzene (1057670-02-6) + 4-(2-azido-2-(dibenzo[b,d]thiophen-2-yl)ethyl)thiomorpholine → 4-(2-(4-(2-chloro-4-fluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(dibenzo[b,d]thiophen-2-yl)ethyl)thiomorpholine

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; regioselective reaction;

DOI:10.1016/j.bmcl.2016.04.015

upstream raw materials:

2-chloro-4-fluorobenzaldehyde

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

Downstream raw materials:

4-(2-chloro-4-fluorophenyl)-1-(1-(dibenzo[b,d]thiophen-2-yl)ethyl)-1H-1,2,3-triazole

Refernces