2-Methyl-1-(2-pyridyl)-1-propylamine

Base Information

• Chemical Name: 2-Methyl-1-(2-pyridyl)-1-propylamine
• CAS No.: 58088-72-5
• Molecular Formula: C9H14N2
• Molecular Weight: 150
• Hs Code.: 2933399090
• Mol file: 58088-72-5.mol

Synonyms:2-Methyl-1-(2-pyridyl)-1-propylamine

Chemical Property of 2-Methyl-1-(2-pyridyl)-1-propylamine

Chemical Property:

• PSA: 38.91000
• LogP: 2.43770
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-1-(2-pyridyl)-1-propylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-1-(2-pyridyl)-1-propylamine

There total 6 articles about 2-Methyl-1-(2-pyridyl)-1-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

→ 2-methyl-1-(pyridin-2-yl)propan-1-amine (58088-72-5)

Guidance literature:

With acetic acid; zinc; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

2-methyl-1-(pyridin-2-yl)-1-azidopropane → 2-methyl-1-(pyridin-2-yl)propan-1-amine (58088-72-5)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/acs.jmedchem.8b00457

Reference yield:

α-isopropyl(2-pyridyl)methanol (102439-95-2) → 2-methyl-1-(pyridin-2-yl)propan-1-amine (58088-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.75 h / 0 °C

2: potassium carbonate; sodium azide / N,N-dimethyl-formamide

3: triphenylphosphine; water / tetrahydrofuran / 16 h / 20 °C

With sodium azide; water; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: |Staudinger Azide Reduction;

DOI:10.1021/acs.jmedchem.8b00457

upstream raw materials:

α-isopropyl(2-pyridyl)methanol

2-bromo-pyridine

2-Cyanopyridine

isopropylmagnesium bromide