Magnesium, bromo(1-methylethyl)-

Base Information

• Chemical Name: Magnesium, bromo(1-methylethyl)-
• CAS No.: 920-39-8
• Molecular Formula: C3H7BrMg
• Molecular Weight: 147.298
• Hs Code.: 29319090
• European Community (EC) Number: 213-056-8
• DSSTox Substance ID: DTXSID1074333
• Mol file: 920-39-8.mol

Synonyms:Isopropylmagnesium Bromide;920-39-8;Magnesium, bromo(1-methylethyl)-;isopropyl magnesium bromide;Isopropylmagnesium bromide, 1.0 M in THF;Isopropylmagnesium bromide, 3 M in 2-MeTHF;MFCD00672110;Bromo(1-methylethyl)magnesium;isopropylmagnesiumbromide;iPrMgBr;i-PrMgBr;EINECS 213-056-8;i-propylmagnesiumbromide;i-propylmagnesium bromide;Bromo-isopropyl-magnesium;iso-propylmagnesium bromide;isopropyl-magnesium bromide;iso-propyl magnesium bromide;iso-propyl-magnesium bromide;SCHEMBL5233;DTXSID1074333;UCJIVFREPMUZDC-UHFFFAOYSA-M;AKOS015902497;Isopropylmagnesium bromide, 3M in 2-MeTHF;E80426;J-802234;i-Propylmagnesium bromide, 2.9M (35wt% ?1wt%) in 2-methyltetrahydrofuran

Chemical Property of Magnesium, bromo(1-methylethyl)-

Chemical Property:

• Appearance/Colour: Clear dark brown or dark gray solution
• Melting Point: 114-116oC
• Boiling Point: 148-154℃
• Flash Point: -17oC
• PSA: 0.00000
• Density: 0.982 g/mL at 25 °C
• LogP: 2.20960
• Storage Temp.: 2-8°C
• Sensitive.: Air & Moisture Sensitive
• Solubility.: Miscible with tetrahydorfuran and diethyl ether. Immiscible with
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 145.95815
• Heavy Atom Count: 5
• Complexity: 6.9

Purity/Quality:

99% ^*data from raw suppliers

Isopropylmagnesium bromide solution ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C
• Statements: 11-19-34-14/15-40-37-17-14
• Safety Statements: 16-26-27-36/37/39-45-43-39-37-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[CH-]C.[Mg+2].[Br-]
• Uses: Isopropylmagnesium bromide is a Grignard reagent used in organic synthesis, especially for the introduction of iso-propyl group to carbonyl compounds. It is also used as a strong base in aprotic solvent.

Technology Process of Magnesium, bromo(1-methylethyl)-

There total 4 articles about Magnesium, bromo(1-methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

isopropyl bromide (75-26-3) → isopropylmagnesium bromide (920-39-8)

Guidance literature:

With magnesium; In tetrahydrofuran-d8; at 25 ℃; under 5171.62 Torr; Concentration; Inert atmosphere; Flow reactor;

DOI:10.3762/bjoc.16.115

Reference yield:

isopropyl bromide (75-26-3) → isopropylmagnesium bromide (920-39-8)

Guidance literature:

With diethyl ether;

Reference yield:

magnesium (7439-95-4) + isopropyl bromide (75-26-3) → isopropylmagnesium bromide (920-39-8)

Guidance literature:

In diethyl ether; for 3.5h; Schlenk technique; Inert atmosphere; Reflux;

DOI:10.1039/c4dt01102c

upstream raw materials:

isopropyl bromide

magnesium

Downstream raw materials:

i-Amyl alcohol

4-Methyl-1-pentanol

2-acetylpropanoic acid ethyl ester

2,4-dimethyl-3-pentanol

Refernces

• 1、 Deng, Yuchao,Wei, Xiao-Jing,Wang, Xiao,Sun, Yuhan,No?l, Timothy. "Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow". supporting information. p. 14532 - 14535. Retrieved 2019/11/21.
• 2、 -. "KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME". Paragraph 0240. . Retrieved 2014/02/15.