(2-Methoxypyridin-3-yl)methanamine

Base Information

• Chemical Name: (2-Methoxypyridin-3-yl)methanamine
• CAS No.: 354824-19-4
• Molecular Formula: C7H10N2O
• Molecular Weight: 138.169
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70588603
• Wikidata: Q82481373
• Mol file: 354824-19-4.mol

Synonyms:354824-19-4;(2-methoxypyridin-3-yl)methanamine;C-(2-Methoxy-pyridin-3-yl)-methylamine;(2-methoxypyridin-3-yl)methylamine;3-aminomethyl-2-methoxypyridine;3-Pyridinemethanamine,2-methoxy-(9CI);C-(2-METHOXY-PYRIDIN-3-YL)METHYLAMINE;3-AMINOMETHYL-2-METHOXY-PYRIDINE;1-(2-METHOXYPYRIDIN-3-YL)METHANAMINE;MFCD09740382;2-METHOXY-3-PYRIDINEMETHANAMINE;3-PYRIDINEMETHANAMINE, 2-METHOXY-;3-(Aminomethyl)-2-methoxypyridine;[(2-methoxypyridin-3-yl)methyl]amine;SCHEMBL1265988;DTXSID70588603;ITKBAOSPYUIRMP-UHFFFAOYSA-N;AMY22969;AKOS000147386;CS-W021066;DS-1600;MCULE-6222919779;PB10680;AC-29631;SY031860;DB-069219;EN300-31268;A874597;J-500841;F2147-1477;(2-Methoxypyridin-3-yl)methylamine

Chemical Property of (2-Methoxypyridin-3-yl)methanamine

Chemical Property:

• Boiling Point: 224.7±25.0 °C(Predicted)
• PKA: 7.60±0.29(Predicted)
• PSA: 48.14000
• Density: 1.090±0.06 g/cm3(Predicted)
• LogP: 1.24920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

99.9% ^*data from raw suppliers

3-Aminomethyl-2-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC=N1)CN

Technology Process of (2-Methoxypyridin-3-yl)methanamine

There total 1 articles about (2-Methoxypyridin-3-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-methoxynicotinaldehyde (71255-09-9) → (2-methoxypyridin-3-yl)methanamine (354824-19-4)

Guidance literature:

2-methoxynicotinaldehyde; With ammonium acetate; sodium cyanoborohydride; In methanol; for 48h;

With hydrogenchloride; In water; pH=2;

Reference yield: 38.0%

(2-methoxypyridin-3-yl)methanamine (354824-19-4) + 6-[4-(cyclopropylmethoxy)phenyl]pyridazine-4-carboxylic acid → 6-[4-(cyclopropylmethoxy)phenyl]-N-[(2-methoxy-3-pyridyl)methyl]pyridazine-4-carboxamide

Guidance literature:

6-[4-(cyclopropylmethoxy)phenyl]pyridazine-4-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

(2-methoxypyridin-3-yl)methanamine; With trimethylamine; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + (2-methoxypyridin-3-yl)methanamine (354824-19-4) + C16H14BrNO5S → N-(4-(4-hydroxy-3-((2-methoxypyridin-3-yl)methyl)-2-thioxothiazolidin-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide

Guidance literature:

(2-methoxypyridin-3-yl)methanamine; With triethylamine; In acetone; for 0.0833333h;

carbon disulfide; In acetone; for 0.5h;

C₁₆H₁₄BrNO₅S; In acetone; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2017.11.023

upstream raw materials:

2-methoxynicotinaldehyde