3-{[1,1'-Biphenyl]-3-YL}prop-2-enoic acid

Base Information

Chemical Name:3-{[1,1'-Biphenyl]-3-YL}prop-2-enoic acid
CAS No.:60521-26-8
Molecular Formula:C15H12O2
Molecular Weight:224.259
Hs Code.:
DSSTox Substance ID:DTXSID40696446
Mol file:60521-26-8.mol

Synonyms:3-{[1,1'-BIPHENYL]-3-YL}PROP-2-ENOIC ACID;3-([1,1'-Biphenyl]-3-yl)prop-2-enoic acid;3-phenylcinnamic acid;DTXSID40696446;QQQNPVHFBDPNNA-UHFFFAOYSA-N;AKOS030239320;(E)-3-([1,1'-biphenyl]-3-yl)acrylic acid

Suppliers and Price of 3-{[1,1'-Biphenyl]-3-YL}prop-2-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-([1,1''-Biphenyl]-3-yl)acrylicAcid
50mg
$ 90.00

Crysdot
3-([1,1'-Biphenyl]-3-yl)acrylicacid 95+%
1g
$ 772.00

Alichem
3-([1,1'-Biphenyl]-3-yl)acrylicacid
1g
$ 634.28

Total 30 raw suppliers

Chemical Property of 3-{[1,1'-Biphenyl]-3-YL}prop-2-enoic acid

Chemical Property:

Boiling Point:424.1±24.0 °C at 760 mmHg
Flash Point:317.7±13.8 °C
PSA：37.30000
Density:1.2±0.1 g/cm³
LogP:3.45140
Storage Temp.:2-8°C
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:224.083729621
Heavy Atom Count:17
Complexity:277

Purity/Quality:

97% ^*data from raw suppliers

3-([1,1''-Biphenyl]-3-yl)acrylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC=CC(=C2)C=CC(=O)O
Use Description (E)-3-Phenylcinnamic acid, a specific chemical compound, serves distinct functions across various fields. In the pharmaceutical sector, it plays a pivotal role as a key intermediate in the synthesis of pharmaceutical compounds, contributing to drug discovery and the development of molecules with potential therapeutic applications. In organic synthesis, (E)-3-phenylcinnaMic acid acts as a versatile building block, enabling the creation of complex molecular structures for research and practical applications. Additionally, in the field of natural product chemistry, it may be explored for its potential contributions to the synthesis of naturally occurring compounds with biological activities. Its applications in pharmaceuticals, organic synthesis, and natural product chemistry underscore its significance in driving innovation, scientific exploration, and potential medical breakthroughs across these different domains.

Technology Process of 3-{[1,1'-Biphenyl]-3-YL}prop-2-enoic acid

There total 8 articles about 3-{[1,1'-Biphenyl]-3-YL}prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 141-82-2
malonic acid

: 1204-60-0
biphenyl-3-carbaldehyde

: 60521-26-8
3-(biphenyl-3-yl)acrylic acid

Guidance literature:: With piperidine; In pyridine; for 2h; Heating;
DOI:10.1002/ardp.200400886

Reference yield:

: 1095-03-0
triphenylborane

: 79432-87-4
methyl m-bromocinnamate

: 60521-26-8
3-(biphenyl-3-yl)acrylic acid

Guidance literature:: With sodium hydroxide; potassium carbonate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In methanol; ethanol; toluene;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 60521-26-8
3-(biphenyl-3-yl)acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / aq. K₂CO₃ / tetrakis(triphenylphosphine)palladium⁽⁰⁾; [1,1'-bis(diphenylphosphine)ferrocene]palladium(II) chloride / toluene; ethanol / 5 h / Heating

2: 91 percent / piperidine / pyridine / 2 h / Heating

With piperidine; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In pyridine; ethanol; toluene; 1: Suzuki coupling / 2: Knoevenagel condensation;
DOI:10.1002/ardp.200400886