2-(4-CHLOROPHENYL)ACETAMIDE

Base Information

• Chemical Name: 2-(4-CHLOROPHENYL)ACETAMIDE
• CAS No.: 20101-92-2
• Molecular Formula: C8H8ClNO
• Molecular Weight: 169.611
• Mol file: 20101-92-2.mol

Synonyms:(4-chlorophenyl)-acetamide;2-(4-Chlorophenyl)acetamide;4-chloro-benzylamide;4-chlorophenylacetamide;4-chloro-Benzeneacetamide;p-chlorophenylacetamide;2-(4-chloro-phenyl)-acetamide;(4-chloro-phenyl)-acetic acid amide;

Chemical Property of 2-(4-CHLOROPHENYL)ACETAMIDE

Chemical Property:

• Melting Point: 183-185 °C
• Boiling Point: 344.9±25.0 °C(Predicted)
• PKA: 16.11±0.40(Predicted)
• PSA: 43.09000
• Density: 1.256±0.06 g/cm3(Predicted)
• LogP: 2.06810
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95% ^*data from raw suppliers

2-(4-chlorophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-CHLOROPHENYL)ACETAMIDE

There total 17 articles about 2-(4-CHLOROPHENYL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-chlorobenzyl cyanide (140-53-4) → 2-(4-chlorophenyl)acetamide (20101-92-2)

Guidance literature:

With dihydrogen peroxide; hexadecyltrimethylammonium methanesulfonate; sodium hydroxide; In water; at 25 ℃; for 1h;

DOI:10.2174/157017809787582708

Reference yield: 96.0%

4-chlorophenylacetic Acid (1878-66-6) → 2-(4-chlorophenyl)acetamide (20101-92-2)

Guidance literature:

With 1H-imidazole; urea; In octane; at 120 ℃; for 24h; Reagent/catalyst;

DOI:10.1039/d0sc01317j

Reference yield: 95.0%

C13H16ClN3O → 2-(4-chlorophenyl)acetamide (20101-92-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

DOI:10.1246/cl.130195

upstream raw materials:

para-chloroacetophenone

potassium cyanide

1-Chloro-4-(chloromethyl)benzene

4-chlorophenacetyl chloride

Downstream raw materials:

N-(2,2,2-trichlor-1-hydroxyethyl)-p-chlorphenylacetamid

3-(4-Chloro-phenyl)-4-pyridin-4-yl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one

4-(o-chlorophenyl)-pyrimidine-2,6-dione

3-(4-Chloro-phenyl)-4,6-diphenyl-1H-pyridin-2-one

Refernces

• 1、 Surmiak, Ewa,Twarda-Clapa, Aleksandra,Zak, Krzysztof M.,Musielak, Bogdan,Tomala, Marcin D.,Kubica, Katarzyna,Grudnik, Przemyslaw,Madej, Mariusz,Jablonski, Mateusz,Potempa, Jan,Kalinowska-Tluscik, Justyna,D?mling, Alexander,Dubin, Grzegorz,Holak, Tad A.. "A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction". . p. 3310 - 3318. Retrieved 2016.
• 2、 Han, Buxing,Ke, Zhengang,Li, Ruipeng,Liu, Zhimin,Tang, Minhao,Wang, Yuepeng,Zeng, Wei,Zhang, Fengtao,Zhao, Yanfei. "A CO2-mediated base catalysis approach for the hydration of triple bonds in ionic liquids". supporting information. p. 9870 - 9875. Retrieved 2021/12/27.
• 3、 -. "PYRROLIDINE DERIVATIVES AS INHIBITOR OF FIBROBLAST ACTIVATION PROTEIN (FAP) AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME". Paragraph 1516; 1520-1522. . Retrieved 2020/11/24.