N-[2-Methyl-3-(4,4,5,5-tetraMethyl[1,3,2]dioxaborolan-2-yl)phenyl]-4-(tert-butyl)benzaMide

Base Information

• Chemical Name: N-[2-Methyl-3-(4,4,5,5-tetraMethyl[1,3,2]dioxaborolan-2-yl)phenyl]-4-(tert-butyl)benzaMide
• CAS No.: 910235-65-3
• Molecular Formula: C24H32BNO3
• Molecular Weight: 393.334
• Mol file: 910235-65-3.mol

Synonyms:N-[2-Methyl-3-(4,4,5,5-tetraMethyl[1,3,2]dioxaborolan-2-yl)phenyl]-4-(tert-butyl)benzaMide;4-(tert-butyl)-N-(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzamide

Chemical Property of N-[2-Methyl-3-(4,4,5,5-tetraMethyl[1,3,2]dioxaborolan-2-yl)phenyl]-4-(tert-butyl)benzaMide

Chemical Property:

• PSA: 47.56000
• LogP: 4.91700

Purity/Quality:

≥95% ^*data from raw suppliers

N-[2-Methyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]-4-(tert-butyl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[2-Methyl-3-(4,4,5,5-tetraMethyl[1,3,2]dioxaborolan-2-yl)phenyl]-4-(tert-butyl)benzaMide

There total 11 articles about N-[2-Methyl-3-(4,4,5,5-tetraMethyl[1,3,2]dioxaborolan-2-yl)phenyl]-4-(tert-butyl)benzaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-methyl-3-( 4,4,5,5-tetramethyl[1,3,2]dioxaborolane-2-yl)phenylamine (882678-96-8) + p-tert-butyl benzoyl chloride (1710-98-1) → 4-tert-butyl-N-[2-methyl-3-(4,4,5,5-tetramethyl-[1,2,3]dioxaborolan-2-yl)-phenyl]-benzamide (910235-65-3)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere; Cooling with ice;

DOI:10.1021/acs.jmedchem.8b01147

Reference yield: 90.0%

N-(3-bromo-2-methylphenyl)-4-(tert-butyl)benzamide (1013116-83-0) + bis(pinacol)diborane (73183-34-3) → 4-tert-butyl-N-[2-methyl-3-(4,4,5,5-tetramethyl-[1,2,3]dioxaborolan-2-yl)-phenyl]-benzamide (910235-65-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.ejmech.2017.03.001

Reference yield: 89.0%

→ 4-tert-butyl-N-[2-methyl-3-(4,4,5,5-tetramethyl-[1,2,3]dioxaborolan-2-yl)-phenyl]-benzamide (910235-65-3)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 90 ℃; Inert atmosphere;

upstream raw materials:

2-methyl-3-( 4,4,5,5-tetramethyl[1,3,2]dioxaborolane-2-yl)phenylamine

p-tert-butyl benzoyl chloride

bis(pinacol)diborane

4-(1,1-dimethylethyl)benzoic acid

Downstream raw materials:

4-{5-[3-(4-tert-butyl-benzoylamino)-2-methylphenyl]-1-methyl-2-oxo-1,2-dihydro-pyridin-3-ylamino}-benzoic acid ethyl ester

4-{6-[3-(4-tert-butyl-benzoylamino)-2-methyl-phenyl]-4-methyl-3-oxo-3,4-dihydro-pyrazin-2-ylamino}-benzoic acid ethyl ester

4-tert-butyl-N-{3-[6-(4-fluoro-3-nitro-phenylamino)-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl]-2-methyl-phenyl}-benzamide

4-tert-butyl-N-{3-[6-(4-formyl-phenylamino)-4-methyl-5-oxo-4,5-dihydro-pyrazin-2-yl]-2-methyl-phenyl}-benzamide