Technology Process of Ethyl 2-(2-(benzyloxy)-5-chlorobenzyl)thiazole-4-carboxylate
There total 6 articles about Ethyl 2-(2-(benzyloxy)-5-chlorobenzyl)thiazole-4-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(5-chloro-2-[(phenylmethyl)oxy]phenyl)ethanethioamide;
With
potassium hydrogencarbonate;
In
1,2-dimethoxyethane;
ethyl Bromopyruvate;
With
pyridine; trifluoroacetic anhydride;
In
1,2-dimethoxyethane;
at 0 - 20 ℃;
Further stages.;
DOI:10.1016/j.bmcl.2008.01.071
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / 2 h / Heating / reflux
2.1: iodine; silver nitrate / ethanol / 16 h / Heating / reflux
3.1: water / ethanol / 1.5 h / 90 °C
4.1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C
5.1: Lawessons reagent / 1,2-dimethoxyethane / 2 h / 20 °C
6.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h
6.2: 0.02 h
6.3: 1.5 h / 0 - 20 °C
With
Lawessons reagent; 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; water; iodine; potassium carbonate; potassium hydrogencarbonate; silver nitrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
1,2-dimethoxyethane; ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Lawessons reagent / 1,2-dimethoxyethane / 2 h / 20 °C
2.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h
2.2: 0.02 h
2.3: 1.5 h / 0 - 20 °C
With
Lawessons reagent; potassium hydrogencarbonate;
In
1,2-dimethoxyethane;
![2-(5-chloro-2-[(phenylmethyl)oxy]phenyl)ethanethioamide](/Databaselist/images/loading.webp)
