2-(2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl)-5-(4-methyl-1-piperazinyl)-3H-benzimidazole hydrochloride

Base Information

Chemical Name:2-(2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl)-5-(4-methyl-1-piperazinyl)-3H-benzimidazole hydrochloride
CAS No.:913653-00-6
Molecular Formula:C₂₉H₂₈ClN₅OS*ClH
Molecular Weight:566.554
Hs Code.:

Synonyms:2-(2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl)-5-(4-methyl-1-piperazinyl)-3H-benzimidazole hydrochloride

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Chemical Property of 2-(2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl)-5-(4-methyl-1-piperazinyl)-3H-benzimidazole hydrochloride

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Technology Process of 2-(2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl)-5-(4-methyl-1-piperazinyl)-3H-benzimidazole hydrochloride

There total 10 articles about 2-(2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl)-5-(4-methyl-1-piperazinyl)-3H-benzimidazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913652-22-9
methyl 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboximidoate hydrochloride

: 54998-08-2
4-(4-methylpiperazino)-1,2-diaminobenzene

: 913653-00-6
2-(2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl)-5-(4-methyl-1-piperazinyl)-3H-benzimidazole hydrochloride

Guidance literature:: methyl 2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboximidoate hydrochloride; 4-(4-methylpiperazino)-1,2-diaminobenzene; In ethanol; at 90 ℃; for 3h;

With hydrogenchloride; In diethyl ether;

Reference yield:

: 913650-03-0
2-(5-chloro-2-[(phenylmethyl)oxy]phenyl)acetamide

: 913653-00-6
2-(2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl)-5-(4-methyl-1-piperazinyl)-3H-benzimidazole hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: Lawessons reagent / 1,2-dimethoxyethane / 2 h / 20 °C

2.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h

2.2: 0.02 h

2.3: 1.5 h / 0 - 20 °C

3.1: sodium hydroxide; water / ethanol / 20 - 60 °C

4.1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

5.1: phosphorus (III) oxychloride / 1 h / 90 °C

6.1: sodium hydride / 20 °C

7.1: ethanol / 3 h / 90 °C

With Lawessons reagent; 4-methyl-morpholine; sodium hydroxide; N-hydroxybenzotriazole ammonium salt; phosphorus (III) oxychloride; water; sodium hydride; potassium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,2-dimethoxyethane; ethanol; dichloromethane;

Reference yield:

: 913652-13-8
2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboxamide

: 913653-00-6
2-(2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl)-5-(4-methyl-1-piperazinyl)-3H-benzimidazole hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus (III) oxychloride / 1 h / 90 °C

2: sodium hydride / 20 °C

3: ethanol / 3 h / 90 °C

With phosphorus (III) oxychloride; sodium hydride; In ethanol;