3-Bromo-5-isoxazolecarboxylic acidmethylester

Base Information

• Chemical Name: 3-Bromo-5-isoxazolecarboxylic acidmethylester
• CAS No.: 272773-11-2
• Molecular Formula: C5H4BrNO3
• Molecular Weight: 205.99
• Hs Code.: 2934999090
• Mol file: 272773-11-2.mol

Synonyms:Methyl 3-bromoisoxazole-5-carboxylate;3-Bromo-5-isoxazolecarboxylic acid methyl ester;

Chemical Property of 3-Bromo-5-isoxazolecarboxylic acidmethylester

Chemical Property:

• Vapor Pressure: 0.00835mmHg at 25°C
• Boiling Point: 267°C at 760 mmHg
• PKA: -7.47±0.50(Predicted)
• Flash Point: 115.3°C
• PSA: 52.33000
• Density: 1.723g/cm³
• LogP: 1.22370

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-Bromoisoxazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-5-isoxazolecarboxylic acidmethylester

There total 1 articles about 3-Bromo-5-isoxazolecarboxylic acidmethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-dibromomethylidenehydroxylamine (74213-24-4) + propynoic acid methyl ester (922-67-8) → methyl 3-bromoisoxazole-5-carboxylate (272773-11-2)

Guidance literature:

With potassium hydrogencarbonate; In ethanol; water; at 20 ℃;

DOI:10.1007/s11696-019-00686-0

Reference yield: 57.7%

methyl 3-bromoisoxazole-5-carboxylate (272773-11-2) → 3-bromo-5-isoxazolecarboxylic acid (6567-35-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1007/s11696-019-00686-0

upstream raw materials:

N-dibromomethylidenehydroxylamine

propynoic acid methyl ester

Downstream raw materials:

3-bromo-5-isoxazolecarboxylic acid