2-Chloro-5-methoxy-pyrimidin-4-ylamine

Base Information

• Chemical Name: 2-Chloro-5-methoxy-pyrimidin-4-ylamine
• CAS No.: 99979-77-8
• Molecular Formula: C5H6ClN3O
• Molecular Weight: 159.575
• Hs Code.: 2933599090
• Mol file: 99979-77-8.mol

Synonyms:2-Chloro-5-Methoxy-pyriMidin-4-ylaMine;2-chloro-5-MethoxypyriMidin-4-aMine;2-Chloro-5-Methoxy-4-pyriMidinaMine

Chemical Property of 2-Chloro-5-methoxy-pyrimidin-4-ylamine

Chemical Property:

• Melting Point: 181-182 °C (decomp)(Solv: ligroine (8032-32-4))
• Boiling Point: 349.6±22.0 °C(Predicted)
• PKA: 2.39±0.10(Predicted)
• PSA: 61.76000
• Density: 1.398±0.06 g/cm3(Predicted)
• LogP: 0.65090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-5-methoxy-4-pyrimidinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The preparation and synthesis of 2-Chloro-5-methoxy-4-pyrimidinamine.

Technology Process of 2-Chloro-5-methoxy-pyrimidin-4-ylamine

There total 2 articles about 2-Chloro-5-methoxy-pyrimidin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,4-dichloro-5-methoxypyrimidine (19646-07-2) → 2-chloro-5-methoxypyrimidin-4-amine (99979-77-8)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; at 100 ℃; for 21h; Inert atmosphere; Sealed tube;

Reference yield:

→ 2-chloro-5-methoxypyrimidin-4-amine (99979-77-8)

Guidance literature:

2,4-Dichlor-5-methoxy-pyrimidin, Na, fl. NH3, Ae.;

Reference yield:

2-chloro-5-methoxypyrimidin-4-amine (99979-77-8) → 2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine (219715-62-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ethyl acetate / 10 h / Reflux

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / water; tert-butyl alcohol / 5 h / 20 °C

3: acetonitrile; methanol / 1.5 h / 20 °C

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In methanol; water; ethyl acetate; acetonitrile; tert-butyl alcohol;

upstream raw materials:

2,4-dichloro-5-methoxypyrimidine

Downstream raw materials:

2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine

2-chloro-6H,7H,8H-pyrimido [5,4-b][1,4]oxazin-7-one

2-bromo-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one

2-((2R,5R)-2-methyl-5-phenylmorpholino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one

Refernces

• 1、 -. "FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF". Paragraph 0345; 0416. . Retrieved 2015/05/19.
• 2、 -. "BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS". Page/Page column 91. . Retrieved 2011/06/16.