3-FLUORO-4-METHYL-5-HYDROXYBENZOIC ACID

Base Information

• Chemical Name: 3-FLUORO-4-METHYL-5-HYDROXYBENZOIC ACID
• CAS No.: 887267-08-5
• Molecular Formula: C8H7FO3
• Molecular Weight: 170.1377832
• Hs Code.: 2918290000
• Mol file: 887267-08-5.mol

Synonyms:3-Fluoro-5-hydroxy-4-methylbenzoic acid; benzoic acid, 3-fluoro-5-hydroxy-4-methyl-3-Fluoro-4-Methyl-5-Hydroxybenzoic Acid; 3-Fluoro-4-methyl-5-hydroxybenzoic acid

Chemical Property of 3-FLUORO-4-METHYL-5-HYDROXYBENZOIC ACID

Chemical Property:

• Vapor Pressure: 1.03E-05mmHg at 25°C
• Boiling Point: 356.9°C at 760 mmHg
• Flash Point: 169.7°C
• PSA: 57.53000
• Density: 1.407g/cm³
• LogP: 1.53790
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Fluoro-5-hydroxy-4-methylbenzoicacid >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUORO-4-METHYL-5-HYDROXYBENZOIC ACID

There total 1 articles about 3-FLUORO-4-METHYL-5-HYDROXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-fluoro-5-hydroxy-4-methylbenzoic acid (887267-08-5)

Guidance literature:

Reference yield:

3-fluoro-5-hydroxy-4-methylbenzoic acid (887267-08-5) + methyl iodide (74-88-4) → methyl 3-fluoro-5-methoxy-4-methylbenzoate

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 25 ℃;

Reference yield:

3-fluoro-5-hydroxy-4-methylbenzoic acid (887267-08-5) → (S)-methyl 3-fluoro-5-(4-(6-isopropylpyridazin-3-yl)phenoxy)-4-((4-methyl-2-oxopyrrolidin-1-yl)methyl)benzoate

Guidance literature:

Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 25 °C

2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / benzene / 25 - 90 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 - 25 °C / Inert atmosphere

3.2: -20 °C

4.1: boron tribromide / dichloromethane / 0 - 25 °C

5.1: caesium carbonate; 2,2,6,6-tetramethylheptane-3,5-dione; copper(l) chloride / 1-methyl-pyrrolidin-2-one / 6.5 h / 25 - 90 °C / Inert atmosphere

5.2: 2.75 h / 20 °C

With N-Bromosuccinimide; 2,2,6,6-tetramethylheptane-3,5-dione; 2,2'-azobis(isobutyronitrile); boron tribromide; sodium hydride; caesium carbonate; copper(l) chloride; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; benzene;

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